Lucrecia García-Martínez1, Irene Gracia-Ahulfinger2, Isabel Machuca3, Sara Cantisán3, Soraya De La Fuente1, Clara Natera3, Elena Pérez-Nadales3, Elisa Vidal3, Antonio Rivero3, Fernando Rodríguez-Lopez2, José Ramón Del Prado1, Julián Torre-Cisneros4. 1. Pharmacy Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain. 2. Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain. 3. Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain. 4. Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain julian.torre.sspa@juntadeandalucia.es.
Abstract
BACKGROUND: There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. OBJECTIVES: To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. METHODS: A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. RESULTS: The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P < 0.001) and Enterococcus faecalis (OR = 0.44; 95% CI = 0.21-0.90; P = 0.03) during the intervention period was lower than in the pre-intervention period. CONCLUSIONS: A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
BACKGROUND: There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. OBJECTIVES: To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. METHODS: A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. RESULTS: The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P < 0.001) and Enterococcus faecalis (OR = 0.44; 95% CI = 0.21-0.90; P = 0.03) during the intervention period was lower than in the pre-intervention period. CONCLUSIONS: A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
Authors: Stephanie A Folan; Kayleigh R Marx; Frank P Tverdek; Issam Raad; Victor E Mulanovich; Jeffrey J Tarrand; Samuel A Shelburne; Samuel L Aitken Journal: Open Forum Infect Dis Date: 2018-07-13 Impact factor: 3.835
Authors: Tobias Siegfried Kramer; Frank Schwab; Michael Behnke; Sonja Hansen; Petra Gastmeier; Seven Johannes Sam Aghdassi Journal: Antimicrob Resist Infect Control Date: 2019-10-21 Impact factor: 4.887