Literature DB >> 27246209

Analysis of Expression and Functions of Histone Deacetylase 6 (HDAC6).

Miao Li1, Yan Zhuang2, Bin Shan3.   

Abstract

Histone deacetylase 6 (HDAC6) is a member of class IIb HDAC family. HDAC6 exists predominantly in the cytoplasm and deacetylates mainly non-histone proteins in the cytoplasm. Via its deacetylase and ubiquitin binding domains, HDAC6 regulates microtubules, cytoskeleton, intracellular trafficking, and cellular responses to stress. HDAC6 plays a central role in physiology and pathobiology in various organs and tissues. Herein we describe the methods for analysis of expression and function of HDAC6 in diverse physiological and pathological contexts.

Entities:  

Keywords:  Acetylation; Chaperone; Histone deacetylase 6; Stress; Ubiquitin

Mesh：

Substances：

Year:  2016        PMID： 27246209     DOI： 10.1007/978-1-4939-3667-0_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  2 in total

1.  Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury.

Authors:  Yingfeng Shi; Liuqing Xu; Jinhua Tang; Lu Fang; Shuchen Ma; Xiaoyan Ma; Jing Nie; Xiaoling Pi; Andong Qiu; Shougang Zhuang; Na Liu
Journal:  Am J Physiol Renal Physiol       Date:  2017-01-04

2.  The Loss of α- and β-Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing.

Authors:  Wajana L Labisso; Ana-Caroline Raulin; Lucky L Nwidu; Artur Kocon; Declan Wayne; Amaia M Erdozain; Benito Morentin; Daniela Schwendener; George Allen; Jack Enticott; Henry K Gerdes; Laura Johnson; John Grzeskowiak; Fryni Drizou; Rebecca Tarbox; Natalia A Osna; Kusum K Kharbanda; Luis F Callado; Wayne G Carter
Journal:  Brain Sci       Date:  2018-09-11
  2 in total

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