Literature DB >> 27246176

Ewing sarcoma: a chronicle of molecular pathogenesis.

Sang Kyum Kim1, Yong-Koo Park2.   

Abstract

Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific genetic alterations. The genetic alterations are translocations between genes of the TET/FET family (TLS/FUS, EWSR1, and TAF15) and genes of the E26 transformation-specific (ETS) family. In this review, we intend to summarize a chronicle of molecular findings of Ewing sarcoma including recent advances and explain resultant molecular pathogenesis.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Chromosomal translocation; Ewing sarcoma; Molecular pathogenesis

Mesh：

Substances：

Year:  2016        PMID： 27246176     DOI： 10.1016/j.humpath.2016.05.008

Source DB:  PubMed          Journal:  Hum Pathol        ISSN： 0046-8177            Impact factor:   3.466


  9 in total

Review 1.  Advances in the Treatment of Pediatric Bone Sarcomas.

Authors:  Patrick J Grohar; Katherine A Janeway; Luke D Mase; Joshua D Schiffman
Journal:  Am Soc Clin Oncol Educ Book       Date:  2017

2.  Ewing Sarcoma of the Pelvis with an Atypical Radiographic Appearance: A Mimicker of Non-malignant Etiologies.

Authors:  Miguel Flores; Anthony Caram; Edward Derrick; John D Reith; Laura Bancroft; Kurt Scherer
Journal:  Cureus       Date:  2016-09-18

3.  Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes.

Authors:  Cheng-Yu Lin; Ankit Shukla; John P Grady; J Lynn Fink; Eloise Dray; Pascal H G Duijf
Journal:  Cancers (Basel)       Date:  2018-01-08       Impact factor: 6.639

Review 4.  Primary Ewing's sarcoma/primitive neuroectodermal tumor of the ileum: case report of a 16-year-old Chinese female and literature review.

Authors:  Teng Li; Fang Zhang; Yarui Cao; Shoubin Ning; Yongmin Bi; Weicheng Xue; Li Ren
Journal:  Diagn Pathol       Date:  2017-05-04       Impact factor: 2.644

5.  EWSR1 Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population.

Authors:  Sara Louati; Nadia Senhaji; Laila Chbani; Sanae Bennis
Journal:  Dis Markers       Date:  2018-09-18       Impact factor: 3.434

6.  EWS-FLI1-mediated tenascin-C expression promotes tumour progression by targeting MALAT1 through integrin α5β1-mediated YAP activation in Ewing sarcoma.

Authors:  Shaohui He; Quan Huang; Jinbo Hu; Lei Li; Yanbin Xiao; Hongyu Yu; Zhitao Han; Ting Wang; Wang Zhou; Haifeng Wei; Jianru Xiao
Journal:  Br J Cancer       Date:  2019-10-25       Impact factor: 7.640

7.  lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation.

Authors:  Xuelei Ruan; Jian Zheng; Xiaobai Liu; Yunhui Liu; Libo Liu; Jun Ma; Qianru He; Chunqing Yang; Di Wang; Heng Cai; Zhen Li; Jing Liu; Yixue Xue
Journal:  Mol Ther Nucleic Acids       Date:  2020-05-08       Impact factor: 8.886

8.  Management of Ewing Sarcoma Family of Tumors: A Short Description of a Rare Primitive Uterine pPNET and Literature Review.

Authors:  Salvatore Pisconti; Giuseppina Della Vittoria Scarpati; Carlo Buonerba; Simona Messinese; Roberta Carella; Massimiliano Di Marzo; Giuseppe Di Lorenzo; Grazia Lazzari; Francesco Perri; Raffaele Solla
Journal:  Onco Targets Ther       Date:  2020-02-14       Impact factor: 4.147

9.  Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.

Authors:  Weili Kong; Tsuyoshi Hayashi; Guillaume Fiches; Qikai Xu; Mamie Z Li; Jianwen Que; Shuai Liu; Wei Zhang; Jun Qi; Netty Santoso; Stephen J Elledge; Jian Zhu
Journal:  Genomics Proteomics Bioinformatics       Date:  2019-09-05       Impact factor: 6.409
  9 in total

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