| Literature DB >> 27246045 |
Siddavaram Nagini1, Jaganathan Kowshik2.
Abstract
The hamster buccal pouch (HBP) carcinogenesis model is one of the most well-characterized animal tumor models used as a prelude to investigate multistage oral carcinogenesis and to assess the efficacy of chemointervention. Hamster buccal pouch carcinomas induced by 7,12-dimethylbenz[a]anthracene (DMBA) show extensive similarities to human oral squamous cell carcinomas. The HBP model offers a number of advantages including a simple and predictable tumor induction procedure, easy accessibility for examination and follow-up of lesions, and reproducibility. This model can be used to test both chemopreventive and chemotherapeutic agents.Entities:
Keywords: Carcinogenesis; Chemointervention; DMBA; Hamster; Oral cancer
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Year: 2016 PMID： 27246045 DOI： 10.1007/978-1-4939-3603-8_29
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745