Literature DB >> 27246044

Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss.

Jose B Saenz1, Joseph Burclaff1,2, Jason C Mills3,4,5.   

Abstract

Parietal cell loss represents the initial step in the sequential progression toward gastric adenocarcinoma. In the setting of chronic inflammation, the expansion of the mucosal response to parietal cell loss characterizes a crucial transition en route to gastric dysplasia. Here, we detail methods for using the selective estrogen receptor modulator tamoxifen as a novel tool to rapidly and reversibly induce parietal cell loss in mice in order to study the mechanisms that underlie these pre-neoplastic events.

Entities:  

Keywords:  Metaplasia; Oxyntic atrophy; Parietal cell loss; Spasmolytic polypeptide-expressing metaplasia (SPEM); Tamoxifen

Mesh：

Substances：

Year:  2016        PMID： 27246044      PMCID： PMC5221414          DOI： 10.1007/978-1-4939-3603-8_28

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  27 in total

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Journal:  Gastroenterology       Date:  2015-02-26       Impact factor: 22.682

2.  Effects of ethanol on parietal cell membrane phospholipids and proton pump function.

Authors:  A R Mazzeo; J Nandi; R A Levine
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3.  Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus.

Authors:  Chad A Reed; Amy K Berndtson; Kenneth P Nephew
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4.  Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection.

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5.  Inducible transgenic mouse models.

Authors:  Thomas L Saunders
Journal:  Methods Mol Biol       Date:  2011

Review 6.  The translation of Helicobacter pylori basic research to patient care.

Authors:  Peter B Ernst; David A Peura; Sheila E Crowe
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7.  Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of "floxed" alleles.

Authors:  Won Jae Huh; Indira U Mysorekar; Jason C Mills
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8.  Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basicity.

Authors:  D W Robertson; J A Katzenellenbogen; J R Hayes; B S Katzenellenbogen
Journal:  J Med Chem       Date:  1982-02       Impact factor: 7.446

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10.  A tamoxifen inducible knock-in allele for investigation of E2A function.

Authors:  Mary E Jones; Motonari Kondo; Yuan Zhuang
Journal:  BMC Dev Biol       Date:  2009-10-12       Impact factor: 1.978
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  27 in total

Review 1.  Are Gastric and Esophageal Metaplasia Relatives? The Case for Barrett's Stemming from SPEM.

Authors:  Ramon U Jin; Jason C Mills
Journal:  Dig Dis Sci       Date:  2018-08       Impact factor: 3.199

Review 2.  Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer.

Authors:  José B Sáenz; Jason C Mills
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2018-02-21       Impact factor: 46.802

3.  Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.

Authors:  Spencer G Willet; Mark A Lewis; Zhi-Feng Miao; Dengqun Liu; Megan D Radyk; Rebecca L Cunningham; Joseph Burclaff; Greg Sibbel; Hei-Yong G Lo; Valerie Blanc; Nicholas O Davidson; Zhen-Ning Wang; Jason C Mills
Journal:  EMBO J       Date:  2018-02-21       Impact factor: 11.598

4.  Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.

Authors:  Joseph Burclaff; Luciana H Osaki; Dengqun Liu; James R Goldenring; Jason C Mills
Journal:  Gastroenterology       Date:  2016-12-05       Impact factor: 22.682

5.  A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.

Authors:  Zhi-Feng Miao; Mahliyah Adkins-Threats; Joseph R Burclaff; Luciana H Osaki; Jing-Xu Sun; Yan Kefalov; Zheng He; Zhen-Ning Wang; Jason C Mills
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6.  Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand Its Intragastric Niche.

Authors:  José B Sáenz; Nancy Vargas; Jason C Mills
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7.  Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.

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8.  Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia.

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9.  Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.

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Review 10.  Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.

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Journal:  Gastroenterology       Date:  2021-10-30       Impact factor: 22.682
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