Literature DB >> 27246043

Characterization of Colorectal Cancer Development in Apc (min/+) Mice.

ILKe Nalbantoglu1, Valerie Blanc2, Nicholas O Davidson2.   

Abstract

The Apc (min/+) mouse provides an excellent experimental model for studying genetic, environmental, and therapeutic aspects of intestinal neoplasia in humans. In this chapter, we will describe techniques for studying colon cancer development in Apc (min/+) mice on C57BL/6J (B6) background, focusing on the roles of environmental modifiers, including Dextran Sulfate Sodium (DSS), high fat diet, and bile acid supplementation in the context of experimental colorectal cancer. This chapter also includes protocols describing extraction and purification of DSS-contaminated RNA, as well as sampling, harvesting, and tissue processing. The common pathologic lesions encountered in these animals are described in detail.

Entities:  

Keywords:  Adenoma; Apc min/+; Bile acids; Colorectal cancer; Dextran sulfate sodium; High fat

Mesh：

Substances：

Year:  2016        PMID： 27246043      PMCID： PMC5061497          DOI： 10.1007/978-1-4939-3603-8_27

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  23 in total

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Review 2.  Smoking and survival of colorectal cancer patients: systematic review and meta-analysis.

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3.  Dextran sodium sulfate inhibition of real-time polymerase chain reaction amplification: a poly-A purification solution.

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Journal:  Inflamm Bowel Dis       Date:  2011-05-25       Impact factor: 5.325

4.  Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.

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Authors:  H S Cooper; L Everley; W C Chang; G Pfeiffer; B Lee; S Murthy; M L Clapper
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Review 9.  APC polymorphisms and the risk of colorectal neoplasia: a HuGE review and meta-analysis.

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Authors:  Yan Xie; Hitoshi Matsumoto; Ilke Nalbantoglu; Thomas A Kerr; Jianyang Luo; Deborah C Rubin; Susan Kennedy; Nicholas O Davidson
Journal:  PLoS One       Date:  2013-06-21       Impact factor: 3.240
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