Literature DB >> 27245887

Extraction and Simultaneous Quantification of Endocannabinoids and Endocannabinoid-Like Lipids in Biological Tissues.

Laura Bindila1, Beat Lutz2.   

Abstract

Extraction and quantification of endocannabinoids (eCBs) from biological tissues are essential to unravel their changes in physiological and pathophysiological conditions. We describe here an analytical protocol for extraction of endocannabinoids, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), endocannabinoid-like lipids such as palmitoyl ethanolamide (PEA) and oleoyl ethanolamide (OEA), as well as arachidonic acid (AA) from biological tissues using liquid-liquid extraction method and simultaneous quantification by liquid chromatography multiple reaction monitoring (LC/MRM).

Entities:  

Keywords:  Endocannabinoid-like lipids; Endocannabinoids; Lipid extraction; Liquid-chromatography; Multiple reaction monitoring

Mesh：

Substances：

Year:  2016        PMID： 27245887     DOI： 10.1007/978-1-4939-3539-0_2

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  12 in total

1.  Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study.

Authors:  Laura Kranaster; Carolin Hoyer; Suna Su Aksay; Jan Malte Bumb; F Markus Leweke; Christoph Janke; Manfred Thiel; Beat Lutz; Laura Bindila; Alexander Sartorius
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2017-03-24       Impact factor: 5.270

2.  Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls.

Authors:  Raissa Lerner; Julia M Post; Shane R Ellis; D R Naomi Vos; Ron M A Heeren; Beat Lutz; Laura Bindila
Journal:  J Lipid Res       Date:  2017-12-05       Impact factor: 5.922

3.  Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring.

Authors:  María Teresa Ramírez-López; Mariam Vázquez; Laura Bindila; Ermelinda Lomazzo; Clementine Hofmann; Rosarío Noemí Blanco; Francisco Alén; María Antón; Juan Decara; Rocío Arco; Daniel Ouro; Laura Orio; Juan Suárez; Beat Lutz; Raquel Gómez de Heras; Fernando Rodríguez de Fonseca
Journal:  Front Behav Neurosci       Date:  2016-11-01       Impact factor: 3.558

4.  A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner.

Authors:  María Teresa Ramírez-López; Mariam Vázquez; Ermelinda Lomazzo; Clementine Hofmann; Rosario Noemi Blanco; Francisco Alén; María Antón; Juan Decara; Rocío Arco; Laura Orio; Juan Suárez; Beat Lutz; Raquel Gómez de Heras; Laura Bindila; Fernando Rodríguez de Fonseca
Journal:  PLoS One       Date:  2017-03-27       Impact factor: 3.240

5.  Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy.

Authors:  Julia M Post; Sebastian Loch; Raissa Lerner; Floortje Remmers; Ermelinda Lomazzo; Beat Lutz; Laura Bindila
Journal:  Front Mol Neurosci       Date:  2018-03-14       Impact factor: 5.639

6.  Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.

Authors:  Julian Jehle; Benedikt Schöne; Sayeh Bagheri; Elina Avraamidou; Melina Danisch; Imke Frank; Philipp Pfeifer; Laura Bindila; Beat Lutz; Dieter Lütjohann; Andreas Zimmer; Georg Nickenig
Journal:  PLoS One       Date:  2018-05-29       Impact factor: 3.240

7.  Cerebrospinal fluid endocannabinoid levels in Gilles de la Tourette syndrome.

Authors:  Kirsten R Müller-Vahl; Laura Bindila; Beat Lutz; Frank Musshoff; Thomas Skripuletz; Charlotte Baumgaertel; Kurt-Wolfram Sühs
Journal:  Neuropsychopharmacology       Date:  2020-04-09       Impact factor: 7.853

8.  Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis.

Authors:  Ev Christin Heide; Laura Bindila; Julia Maria Post; Dörthe Malzahn; Beat Lutz; Jana Seele; Roland Nau; Sandra Ribes
Journal:  Front Immunol       Date:  2018-11-16       Impact factor: 7.561

9.  Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses.

Authors:  Tina Zimmermann; Julia C Bartsch; Annika Beer; Ermelinda Lomazzo; Stephan Guggenhuber; Maren D Lange; Laura Bindila; Hans-Christian Pape; Beat Lutz
Journal:  Neuropsychopharmacology       Date:  2018-11-15       Impact factor: 7.853

10.  Association of Innate and Acquired Aerobic Capacity With Resilience in Healthy Adults: Protocol for a Randomized Controlled Trial of an 8-Week Web-Based Physical Exercise Intervention.

Authors:  David T Ochmann; Keito F A Philippi; Peter Zeier; Magdalena Sandner; Barlo Hillen; Elmo W I Neuberger; Inigo Ruiz de Azua; Klaus Lieb; Michèle Wessa; Beat Lutz; Perikles Simon; Alexandra Brahmer
Journal:  JMIR Res Protoc       Date:  2021-11-29
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