Abbas Arj1, Mohsen Razavi Zade2, Maryam Yavari1, Hossein Akbari3, Batol Zamani4,5, Zatollah Asemi6. 1. Department of Gastroenterology, Kashan University of Medical Sciences, Kashan, Iran. 2. Department of Gastroenterology, Kashan University of Medical Sciences, Kashan, Iran. mohsen_razavizade@yahoo.com. 3. Department of Biostatistics, Kashan University of Medical Sciences, Kashan, Iran. 4. Department of Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran. 5. Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran. 6. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. asemi_r@yahoo.com.
Abstract
OBJECTIVE: Limited data are available reporting the effect of proton pump inhibitor (PPI) use on changes in bone mineral density (BMD). The aim of this study was to investigate the relationship between PPI use and BMD. METHODS: The current cross-sectional study included 80 patients (31 male and 49 female) aged 20-45 years old without history of hip fracture with a follow-up of at least 2 years. The study was carried out in 40 daily PPI users and 40 PPI non-users. Femur and posterior-anterior spine BMD were quantified by dual-energy X-ray absorptiometry in all participants. The relationship between use of PPI and BMD was tested by multivariate linear regression analysis adjusted for age, sex, BMI and serum vitamin D levels. RESULTS: Our study demonstrated that mean femoral T-scores were significant between PPI and non-user groups (-0.44 ± 1.11 vs. +0.19 ± 0.95, P = 0.007). In addition, the frequency of femoral osteoporosis and osteopenia in the exposed group was significantly more in the control group (P = 0.04). Mean femoral Z-scores, lumbar spine T-score and lumbar spine Z-score were not statistically different between PPI and non-user groups. The linear regression analysis revealed that there was no association between PPI and non-users, and lumbar spine T-score. CONCLUSION: Overall, the results of this study showed that PPI use in subjects without risk factors of osteoporosis determined by the femoral T-score compared with the control group was associated with increased risk of developing osteoporosis and osteopenia in the femur bones.
OBJECTIVE: Limited data are available reporting the effect of proton pump inhibitor (PPI) use on changes in bone mineral density (BMD). The aim of this study was to investigate the relationship between PPI use and BMD. METHODS: The current cross-sectional study included 80 patients (31 male and 49 female) aged 20-45 years old without history of hip fracture with a follow-up of at least 2 years. The study was carried out in 40 daily PPI users and 40 PPI non-users. Femur and posterior-anterior spine BMD were quantified by dual-energy X-ray absorptiometry in all participants. The relationship between use of PPI and BMD was tested by multivariate linear regression analysis adjusted for age, sex, BMI and serum vitamin D levels. RESULTS: Our study demonstrated that mean femoral T-scores were significant between PPI and non-user groups (-0.44 ± 1.11 vs. +0.19 ± 0.95, P = 0.007). In addition, the frequency of femoral osteoporosis and osteopenia in the exposed group was significantly more in the control group (P = 0.04). Mean femoral Z-scores, lumbar spine T-score and lumbar spine Z-score were not statistically different between PPI and non-user groups. The linear regression analysis revealed that there was no association between PPI and non-users, and lumbar spine T-score. CONCLUSION: Overall, the results of this study showed that PPI use in subjects without risk factors of osteoporosis determined by the femoral T-score compared with the control group was associated with increased risk of developing osteoporosis and osteopenia in the femur bones.
Authors: C M Bastos; I M Araújo; M H Nogueira-Barbosa; C E G Salmon; F J A de Paula; L E A Troncon Journal: Osteoporos Int Date: 2017-04-12 Impact factor: 4.507
Authors: Peter Janu; Ahmad Bassel Shughoury; Kumar Venkat; Daniel Hurwich; Tom Galouzis; James Siatras; Dennis Streeter; Kathleen Korman; George Mavrelis; Peter Mavrelis Journal: Surg Innov Date: 2019-08-20 Impact factor: 2.058
Authors: Anna F Henderson; Soofia M Khan; Lindsey N Hornung; Vincent A Mukkada; Heidi J Kalkwarf Journal: J Pediatr Gastroenterol Nutr Date: 2020-12 Impact factor: 3.288