Literature DB >> 27241781

Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates.

Brittany B Lewis1, Rebecca A Carter1, Eric G Pamer2.   

Abstract

Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Clostridium difficile; Secondary bile acid

Mesh：

Substances：

Year:  2016        PMID： 27241781      PMCID： PMC5050091          DOI： 10.1016/j.anaerobe.2016.05.010

Source DB:  PubMed          Journal:  Anaerobe        ISSN： 1075-9964            Impact factor:   3.331


  39 in total

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2.  An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis.

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5.  Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence.

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6.  Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection.

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7.  Detection and elimination of a novel non-toxigenic Clostridioides difficile strain from the microbiota of a mouse colony.

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9.  Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions.

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10.  Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids.

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