Literature DB >> 27241343

Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand.

June M Tordoff1, Nagham J Ailabouni2, Dorothy P Browne2, Hesham S Al-Sallami2, Andrew R Gray3.   

Abstract

UNLABELLED: Background Despite warnings of possible serious events, and reports of little benefit, antipsychotic agents are commonly prescribed in residential care for older people with dementia. A residential care provider (RCP) in New Zealand sought to examine and improve prescribing in some of their facilities. Objective To examine changes following a range of interventions implemented by a RCP to improve the prescribing of antipsychotics. Setting Thirteen dementia and psychogeriatric units in New Zealand managed by a RCP. Method An audit (n = 228 residents) was undertaken in thirteen dementia and psychogeriatric units in New Zealand in July-September 2011. A modified Best Practice Advocacy Centre (bpac(nz)) tool was used to examine antipsychotic prescribing, the administration of "when required" (PRN) antipsychotic doses and antipsychotic-related documentation (e.g. documenting of "target behaviour identified" and "need to monitor for adverse effects"). Prescribing for some central nervous system agents and fractures and fall rates were also examined. Some educational, managerial, environmental, recreational and resident-specific interventions were implemented post-audit. The audit (n = 233) was repeated in July-September 2013. MAIN OUTCOME MEASURES: (1) Number of residents prescribed and administered antipsychotics (2) Documentation of antipsychotic-related information in residents' notes. Results The administration of antipsychotics and prescribing of regular doses (±PRN) decreased about a quarter from 2011 to 2013: 50.4-38.2, and 49.1-36.5 % (ORs 0.60, 0.57 respectively, both p < 0.001), and prescribing for any antipsychotic dose (including PRN only) decreased: 60.5-50.6 % (OR 0.67, p = 0.003). Documenting of "target behaviour identified" significantly increased from 54.3 to 71.2 %, (OR 1.99, p = 0.017) and documenting of the "need to monitor for adverse effects" increased non-significantly (30.4-46.6 %, p = 0.098); both falling short of the 90 % goal set by bpac(nz). Benzodiazepine prescribing significantly decreased [39.0-25.8 %, (OR 0.59, p < 0.001)]. Conclusions Following a range of interventions, antipsychotic prescribing, administration and some related documentation improved in dementia and psychogeriatric units in New Zealand. Future studies should aim to identify the most effective of these interventions so they can be considered for implementing in similar settings.

Entities:  

Keywords:  Antipsychotics; Dementia; Elderly; New Zealand; Nursing homes; Older adults

Mesh:

Substances:

Year:  2016        PMID: 27241343     DOI: 10.1007/s11096-016-0318-1

Source DB:  PubMed          Journal:  Int J Clin Pharm


  28 in total

Review 1.  Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.

Authors:  Alicia Ruelaz Maher; Margaret Maglione; Steven Bagley; Marika Suttorp; Jian-Hui Hu; Brett Ewing; Zhen Wang; Martha Timmer; David Sultzer; Paul G Shekelle
Journal:  JAMA       Date:  2011-09-28       Impact factor: 56.272

Review 2.  The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease.

Authors:  C Ballard; J Waite
Journal:  Cochrane Database Syst Rev       Date:  2006-01-25

3.  "The way we do things around here": an international comparison of treatment culture in nursing homes.

Authors:  Carmel M Hughes; Ailis Donnelly; Simon A Moyes; Kathy Peri; Shane Scahill; Charlotte Chen; Brendan McCormack; Ngaire Kerse
Journal:  J Am Med Dir Assoc       Date:  2011-04-21       Impact factor: 4.669

4.  Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials.

Authors:  Lon S Schneider; Karen S Dagerman; Philip Insel
Journal:  JAMA       Date:  2005-10-19       Impact factor: 56.272

Review 5.  Safety of benzodiazepines in the geriatric population.

Authors:  Subramoniam Madhusoodanan; Olivera J Bogunovic
Journal:  Expert Opin Drug Saf       Date:  2004-09       Impact factor: 4.250

Review 6.  Meta-analysis of the impact of 9 medication classes on falls in elderly persons.

Authors:  John C Woolcott; Kathryn J Richardson; Matthew O Wiens; Bhavini Patel; Judith Marin; Karim M Khan; Carlo A Marra
Journal:  Arch Intern Med       Date:  2009-11-23

7.  Unexplained variation across US nursing homes in antipsychotic prescribing rates.

Authors:  Yong Chen; Becky A Briesacher; Terry S Field; Jennifer Tjia; Denys T Lau; Jerry H Gurwitz
Journal:  Arch Intern Med       Date:  2010-01-11

8.  Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials.

Authors:  Dae Hyun Kim; Rebecca T Brown; Eric L Ding; Douglas P Kiel; Sarah D Berry
Journal:  J Am Geriatr Soc       Date:  2011-06-07       Impact factor: 5.562

Review 9.  Interventions to reduce inappropriate prescribing of antipsychotic medications in people with dementia resident in care homes: a systematic review.

Authors:  Jo Thompson Coon; Rebecca Abbott; Morwenna Rogers; Rebecca Whear; Stephen Pearson; Iain Lang; Nick Cartmell; Ken Stein
Journal:  J Am Med Dir Assoc       Date:  2014-08-08       Impact factor: 4.669

10.  Efficacy and safety of atypical antipsychotic drug treatment for dementia: a systematic review and meta-analysis.

Authors:  Lin Tan; Lan Tan; Hui-Fu Wang; Jun Wang; Chen-Chen Tan; Meng-Shan Tan; Xiang-Fei Meng; Chong Wang; Jin-Tai Yu
Journal:  Alzheimers Res Ther       Date:  2015-04-20       Impact factor: 6.982

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.