Thibault De Maesschalck1, Nicolas Dulguerov1, Francesca Caparrotti2, Paolo Scolozzi3, Cristina Picardi2, Nicolas Mach4, Nikolaos Koutsouvelis2, Pavel Dulguerov5. 1. Department of Oto-Rhino-Laryngology - Head and Neck Surgery, Geneva University Hospital, Geneva, Switzerland. 2. Department of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland. 3. Department of Maxillo-Facial Surgery, Geneva University Hospital, Geneva, Switzerland. 4. Department of Medical Oncology, Geneva University Hospital, Geneva, Switzerland. 5. Department of Oto-Rhino-Laryngology - Head and Neck Surgery, Geneva University Hospital, Geneva, Switzerland. pavel.dulguerov@hcuge.ch.
Abstract
BACKGROUND: Modern techniques of radiotherapy are supposed to decrease the incidence of osteoradionecrosis of the mandible (ORNM). The purpose of this study was to compare the incidence of ORNM after intensity-modulated radiotherapy (IMRT) in comparison to conventional 3D conformal radiotherapy techniques (conventional RT). METHODS: We conducted a retrospective study of consecutive unselected patients treated in a single institution between 2002 and 2012. To minimize confounding effects, only patients with oropharyngeal carcinoma without surgery of the primary site were included. RESULTS: The cohorts included 145 patients in the conventional RT group and 89 patients in the IMRT group. Total incidence rate of ORNM was similar for both groups with rates of 11% versus 10% (n = 16 for conventional RT and n = 9 for IMRT; p = 1.0). Subanalysis revealed more ORNM in T4 classified lesions with IMRT (p = .007). Analysis of different risk factors showed no statistically significant difference between ORNM and no-ORNM patients. CONCLUSION: We found no reduction in ORNM with IMRT.
BACKGROUND: Modern techniques of radiotherapy are supposed to decrease the incidence of osteoradionecrosis of the mandible (ORNM). The purpose of this study was to compare the incidence of ORNM after intensity-modulated radiotherapy (IMRT) in comparison to conventional 3D conformal radiotherapy techniques (conventional RT). METHODS: We conducted a retrospective study of consecutive unselected patients treated in a single institution between 2002 and 2012. To minimize confounding effects, only patients with oropharyngeal carcinoma without surgery of the primary site were included. RESULTS: The cohorts included 145 patients in the conventional RT group and 89 patients in the IMRT group. Total incidence rate of ORNM was similar for both groups with rates of 11% versus 10% (n = 16 for conventional RT and n = 9 for IMRT; p = 1.0). Subanalysis revealed more ORNM in T4 classified lesions with IMRT (p = .007). Analysis of different risk factors showed no statistically significant difference between ORNM and no-ORNM patients. CONCLUSION: We found no reduction in ORNM with IMRT.
Authors: Theodoros N Teknos; J Grecula; A Agrawal; M O Old; E Ozer; R Carrau; S Kang; J Rocco; D Blakaj; V Diavolitsis; B Kumar; P Kumar; Q Pan; M Palettas; L Wei; R Baiocchi; P Savvides Journal: Invest New Drugs Date: 2018-12-19 Impact factor: 3.850