Margarita S Biragova1, Svetlana A Gracheva2, Alexandra M Glazunova3, Sergey A Martynov4, Irina N Ulaynova5, Alexandr V Ilyin6, Yury I Philippov7, Guliya M Musaeva8, Minara S Shamkhalova9, Marina V Shestakova10. 1. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: rituzik-uezd@mail.ru. 2. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: sgracheva@mail.ru. 3. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: ivetta_86@inbox.ru. 4. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: smartynov@inbox.ru. 5. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: org@endocrincentr.ru. 6. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: alexilin2005@yandex.ru. 7. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: yuriyivanovich@gmail.com. 8. I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya st., Moscow 119991, Russia. Electronic address: gulia2004@bk.ru. 9. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation. Electronic address: shamkhalova@mail.ru. 10. Endocrinology Research Centre, 11 Dmitriya Ulyanova Street, Moscow 117036, Russian Federation; I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya st., Moscow 119991, Russia. Electronic address: nephro@endocrincentr.ru.
Abstract
AIMS: The objective of our study was to evaluate the role of mineral and bone metabolism disorders associated with chronic kidney disease (MBD-CKD) in the development and progression of cardiac and renal pathology in patients with type 1 diabetes mellitus (T1DM) of long duration. METHODS: We investigated 96 patients with T1DM of long duration, with CKD at different stages (0-5), including patients on hemodialysis (HD) and with kidney transplantation (KT). Along with overall clinical examination, we assessed markers of MBD (calcium, phosphorus, parathormone, vitamin D, fibroblast growth factor (FGF) 23) and levels of cardiac injury marker (atrial natriuretic peptide, NT-proBNP). Multispiral computer tomography with Agatston index calculation was also included. RESULTS: Decreased kidney function was associated with increased of levels phosphorus, parathormone, FGF 23, and vitamin D deficiency, with the highest deviation from the reference ranges seen in patients on HD with a very high risk of cardiovascular events. In KT patients with satisfactory graft function, these parameters were at the same levels as in patients with CKD stages 0-4. Progression of cardiovascular pathology was accompanied by elevation of NT-proBNP levels as CKD duration increased, decreased glomerular filtration rate, and were correlated with the main parameters of mineral homeostasis. The severity of coronary arteries calcification was associated with patient age and duration of T1DM and arterial hypertension. CONCLUSIONS: Development and progression of kidney dysfunction is accompanied by MBD, a significant factor in progression of cardiac pathology, which remains a major cause of mortality in this patient population.
AIMS: The objective of our study was to evaluate the role of mineral and bone metabolism disorders associated with chronic kidney disease (MBD-CKD) in the development and progression of cardiac and renal pathology in patients with type 1 diabetes mellitus (T1DM) of long duration. METHODS: We investigated 96 patients with T1DM of long duration, with CKD at different stages (0-5), including patients on hemodialysis (HD) and with kidney transplantation (KT). Along with overall clinical examination, we assessed markers of MBD (calcium, phosphorus, parathormone, vitamin D, fibroblast growth factor (FGF) 23) and levels of cardiac injury marker (atrial natriuretic peptide, NT-proBNP). Multispiral computer tomography with Agatston index calculation was also included. RESULTS: Decreased kidney function was associated with increased of levels phosphorus, parathormone, FGF 23, and vitamin D deficiency, with the highest deviation from the reference ranges seen in patients on HD with a very high risk of cardiovascular events. In KT patients with satisfactory graft function, these parameters were at the same levels as in patients with CKD stages 0-4. Progression of cardiovascular pathology was accompanied by elevation of NT-proBNP levels as CKD duration increased, decreased glomerular filtration rate, and were correlated with the main parameters of mineral homeostasis. The severity of coronary arteries calcification was associated with patient age and duration of T1DM and arterial hypertension. CONCLUSIONS: Development and progression of kidney dysfunction is accompanied by MBD, a significant factor in progression of cardiac pathology, which remains a major cause of mortality in this patient population.
Authors: Bruce A Perkins; Leif Erik Lovblom; Sebastien O Lanctôt; Krista Lamb; David Z I Cherney Journal: Diabetologia Date: 2021-03-04 Impact factor: 10.122