| Literature DB >> 27240021 |
Nathan L Meyers1, Krystal A Fontaine1, G Renuka Kumar1, Melanie Ott2.
Abstract
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. To establish and maintain chronic infection, HCV extensively rearranges cellular organelles to generate distinct compartments for viral RNA replication and virion assembly. Here, we review our current knowledge of how HCV proliferates and remodels ER-derived membranes while preserving and expanding associated lipid droplets during viral infection. Unraveling the molecular mechanisms responsible for HCV-induced membrane reorganization will enhance our understanding of the HCV life-cycle, the associated liver pathology, and the biology of the ER:lipid droplet interface in general.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27240021 PMCID： PMC5477849 DOI： 10.1016/j.ceb.2016.05.003
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382