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Literature DB >> 27238421

Does Longer Lifespan Mean Longer Healthspan?

Abstract

Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to lifespan extension also improving healthspan?

Entities: Chemical Disease Gene Species

Keywords: Caenorhabditis elegans; TOR signaling; aging; insulin/IGF-1 signaling; longevity; mice

Mesh：

Substances：

Year: 2016 PMID： 27238421 PMCID： PMC4969078 DOI： 10.1016/j.tcb.2016.05.002

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

15 in total

Review 1. Modulating mTOR in aging and health.

Authors: Simon C Johnson; Maya Sangesland; Matt Kaeberlein; Peter S Rabinovitch
Journal: Interdiscip Top Gerontol Date: 2014-10-13

2. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.

Authors: Ankita Bansal; Lihua J Zhu; Kelvin Yen; Heidi A Tissenbaum
Journal: Proc Natl Acad Sci U S A Date: 2015-01-05 Impact factor: 11.205

3. A C. elegans mutant that lives twice as long as wild type.

Authors: C Kenyon; J Chang; E Gensch; A Rudner; R Tabtiang
Journal: Nature Date: 1993-12-02 Impact factor: 49.962

Review 4. Ageing and protein aggregation-mediated disorders: from invertebrates to mammals.

Authors: Andrew Dillin; Ehud Cohen
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2011-01-12 Impact factor: 6.237

Review 5. Macronutrients and caloric intake in health and longevity.

Authors: Samantha M Solon-Biet; Sarah J Mitchell; Rafael de Cabo; David Raubenheimer; David G Le Couteur; Stephen J Simpson
Journal: J Endocrinol Date: 2015-05-28 Impact factor: 4.286

6. mTOR inhibition improves immune function in the elderly.

Authors: Joan B Mannick; Giuseppe Del Giudice; Maria Lattanzi; Nicholas M Valiante; Jens Praestgaard; Baisong Huang; Michael A Lonetto; Holden T Maecker; John Kovarik; Simon Carson; David J Glass; Lloyd B Klickstein
Journal: Sci Transl Med Date: 2014-12-24 Impact factor: 17.956

7. Rapamycin extends murine lifespan but has limited effects on aging.

Authors: Frauke Neff; Diana Flores-Dominguez; Devon P Ryan; Marion Horsch; Susanne Schröder; Thure Adler; Luciana Caminha Afonso; Juan Antonio Aguilar-Pimentel; Lore Becker; Lillian Garrett; Wolfgang Hans; Moritz M Hettich; Richard Holtmeier; Sabine M Hölter; Kristin Moreth; Cornelia Prehn; Oliver Puk; Ildikó Rácz; Birgit Rathkolb; Jan Rozman; Beatrix Naton; Rainer Ordemann; Jerzy Adamski; Johannes Beckers; Raffi Bekeredjian; Dirk H Busch; Gerhard Ehninger; Jochen Graw; Heinz Höfler; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Jörg Stypmann; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Helmut Fuchs; Valérie Gailus-Durner; Martin Hrabe de Angelis; Dan Ehninger
Journal: J Clin Invest Date: 2013-07-25 Impact factor: 14.808

Review 8. Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.

Authors: Sofiya Milman; Nir Barzilai
Journal: Cold Spring Harb Perspect Med Date: 2015-12-04 Impact factor: 6.915

9. Rapamycin slows aging in mice.

Authors: John E Wilkinson; Lisa Burmeister; Susan V Brooks; Chi-Chao Chan; Sabrina Friedline; David E Harrison; James F Hejtmancik; Nancy Nadon; Randy Strong; Lauren K Wood; Maria A Woodward; Richard A Miller
Journal: Aging Cell Date: 2012-06-04 Impact factor: 9.304

10. Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.

Authors: Kathleen E Fischer; Jonathan A L Gelfond; Vanessa Y Soto; Chul Han; Shinichi Someya; Arlan Richardson; Steven N Austad
Journal: PLoS One Date: 2015-05-15 Impact factor: 3.240

26 in total

1. Two conserved epigenetic regulators prevent healthy ageing.

Authors: Jie Yuan; Si-Yuan Chang; Shi-Gang Yin; Zhi-Yang Liu; Xiu Cheng; Xi-Juan Liu; Qiang Jiang; Ge Gao; De-Ying Lin; Xin-Lei Kang; Shi-Wei Ye; Zheng Chen; Jiang-An Yin; Pei Hao; Lubin Jiang; Shi-Qing Cai
Journal: Nature Date: 2020-02-26 Impact factor: 49.962

2. Genetic variation in glia-neuron signalling modulates ageing rate.

Authors: Jiang-An Yin; Ge Gao; Xi-Juan Liu; Zi-Qian Hao; Kai Li; Xin-Lei Kang; Hong Li; Yuan-Hong Shan; Wen-Li Hu; Hai-Peng Li; Shi-Qing Cai
Journal: Nature Date: 2017-11-08 Impact factor: 49.962

Review 3. Elixir of Life: Thwarting Aging With Regenerative Reprogramming.

Authors: Ergin Beyret; Paloma Martinez Redondo; Aida Platero Luengo; Juan Carlos Izpisua Belmonte
Journal: Circ Res Date: 2018-01-05 Impact factor: 17.367

Review 4. The relationships and interactions between age, exercise and physiological function.

Authors: Norman R Lazarus; Janet M Lord; Stephen D R Harridge
Journal: J Physiol Date: 2018-12-17 Impact factor: 5.182

Review 5. Nanodelivery of phytobioactive compounds for treating aging-associated disorders.

Authors: Oleh Lushchak; Olha Strilbytska; Alexander Koliada; Alina Zayachkivska; Nadia Burdyliuk; Ihor Yurkevych; Kenneth B Storey; Alexander Vaiserman
Journal: Geroscience Date: 2019-11-04 Impact factor: 7.713

6. An Alkaline Protease-Digestion of Silkworm Powder Enhances Its Effects Over Healthspan, Autophagy, and Mitochondria Function in a Rotenone-Induced Drosophila Model.

Authors: Linh Xuan Mai; Sang-Kug Kang; You-Young Jo; Phuong Nguyen; A-Young Kim; Kee-Young Kim; Nam-Suk Kim; Young Ho Koh
Journal: Front Nutr Date: 2022-06-16