Thomas G Liman1,2,3, Lars Neeb4,5, Jana Rosinski4, Uwe Reuter5, Matthias Endres4,5,6,7,8,9. 1. Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany. thomas.liman@charite.de. 2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. thomas.liman@charite.de. 3. Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany. thomas.liman@charite.de. 4. Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany. 5. Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany. 6. German Center for Neurodegenerative Disease (DZNE), Charité - Universitätsmedizin, Berlin, Germany. 7. Excellence Cluster Neurocure, Charité - Universitätsmedizin, Berlin, Germany. 8. German Center for Cardiovascular Research (DZHK), Berlin, Germany. 9. Berlin Institute of Health (BIH), Berlin, Germany.
Abstract
BACKGROUND: Endothelial dysfunction may contribute to the pathophysiology of migraine with aura. Stromal cell-derived factor-1 alpha (SDF-1α) is involved in the maintenance of endothelial integrity via mobilization of vascular stem cells. OBJECTIVES: We sought to determine whether SDF-1α levels are decreased in women with MA. METHODS: In this post hoc analysis of a case-cohort study, levels of SDF-1α were determined by enzyme-linked immunosorbent assay. Endothelial function was assessed using peripheral arterial tonometry. Arterial stiffness was assessed by fingertip tonometry derived and heart-rate-adjusted augmentation index (AI). RESULTS: Twenty-eight women with MA and 27 age-matched healthy women were included in this study. Levels of SDF-1α were significantly lower in women with MA compared to age- and risk factor-matched healthy women (1763 ± 281 vs 2013 ± 263 pg/mL, P = 0.006). SDF-1α levels were positively correlated with AI in healthy women (r = 0.49, P = 0.009), but not in women with MA (r = 0.05, P = 0.78). SDF-1α levels were negatively correlated with CD144-positive endothelial microparticles (EMP; r = -0.31, P = .02), and activated CD62E-positive EMP (r = -0.35, P = .01). CONCLUSION: Levels of SDF-1α are decreased in women with MA and are associated with EMPs as a surrogate marker of endothelial dysfunction. This might contribute to the pathophysiology and vascular risk in MA, but evidence from larger prospective studies is warranted.
BACKGROUND: Endothelial dysfunction may contribute to the pathophysiology of migraine with aura. Stromal cell-derived factor-1 alpha (SDF-1α) is involved in the maintenance of endothelial integrity via mobilization of vascular stem cells. OBJECTIVES: We sought to determine whether SDF-1α levels are decreased in women with MA. METHODS: In this post hoc analysis of a case-cohort study, levels of SDF-1α were determined by enzyme-linked immunosorbent assay. Endothelial function was assessed using peripheral arterial tonometry. Arterial stiffness was assessed by fingertip tonometry derived and heart-rate-adjusted augmentation index (AI). RESULTS: Twenty-eight women with MA and 27 age-matched healthy women were included in this study. Levels of SDF-1α were significantly lower in women with MA compared to age- and risk factor-matched healthy women (1763 ± 281 vs 2013 ± 263 pg/mL, P = 0.006). SDF-1α levels were positively correlated with AI in healthy women (r = 0.49, P = 0.009), but not in women with MA (r = 0.05, P = 0.78). SDF-1α levels were negatively correlated with CD144-positive endothelial microparticles (EMP; r = -0.31, P = .02), and activated CD62E-positive EMP (r = -0.35, P = .01). CONCLUSION: Levels of SDF-1α are decreased in women with MA and are associated with EMPs as a surrogate marker of endothelial dysfunction. This might contribute to the pathophysiology and vascular risk in MA, but evidence from larger prospective studies is warranted.