Jordi Remon1, Nicolas Girard2, Julien Mazieres3, Eric Dansin4, Eric Pichon5, Laurent Greillier6, Catherine Dubos7, Colin R Lindsay1, Benjamin Besse8. 1. Gustave Roussy Cancer Campus, Villejuif, France. 2. Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France. Electronic address: nicolas.girard@chu-lyon.fr. 3. University Hospital of Toulouse, University of Toulouse III (Paul Sabatier), Toulouse, France. 4. CLCC Oscar-Lambret, Lille, France. 5. CHRU de Tours-Hospital Bretonneau, Tours, France. 6. Aix Marseille University-Assistance Publique Hôpitaux de Marseille, Marseille, France. 7. Centre de Lutte Contre le Cancer François Baclesse, Caen, France. 8. Gustave Roussy Cancer Campus, Villejuif, France; University Paris-Sud and Gustave Roussy Cancer Campus, Villejuif, France.
Abstract
BACKGROUND: Sunitinib is a potent oral tyrosine kinase inhibitor of VEGFRs, KIT, and PDGFRs. In a single arm phase II trial, sunitinib has demonstrated its potential activity in refractory thymic carcinoma (TC) and thymoma (T). Taking advantage of the French RYTHMIC network prospective database, we investigated the off-label efficacy of sunitinib in previously-treated thymic epithelial tumors (TETs) patients not included in a clinical trial. METHODS: RYTHMIC database started in 2012, and prospectively collects clinical, imaging, treatment, and follow-up data of all patients diagnosed with TET, for whom management is discussed at a national multidisciplinary tumor board. All patients who received sunitinib were selected for this analysis. RESULTS: 28 patients from 7 institutions were identified, including 20 TC and 8T; 32% of patients were females, and median age was 50 years. Fifteen patients (54%) received sunitinib as ≥4th line treatment. The initial daily dose of sunitinib was 50mg in 11 patients, 37.5mg in 16 patients and 25mg in 1 patient. Sunitinib adverse events were all manageable and tolerable; 8 patients had to stop sunitinib due to toxicity after a median duration of treatment of 2.7 months. In the overall population, disease control rate was of 63% (86% for T, and 55% for TC); overall response rate was 22% (29% for T, and 20% for TC). Median PFS in the whole population was 3.7 months (5.4 months for T, and 3.3 months for TC, p=0.097). The median overall survival in the whole population was 15.4 months: survival was not reached for T, and was 12.3 months for TC patients (p=0.043). CONCLUSION: Sunitinib is an active treatment in TETs irrespective of histological subtype, supporting the use of tyrosine kinase inhibitors with anti-angiogenic activity as alternative treatment options in refractory disease.
BACKGROUND:Sunitinib is a potent oral tyrosine kinase inhibitor of VEGFRs, KIT, and PDGFRs. In a single arm phase II trial, sunitinib has demonstrated its potential activity in refractory thymic carcinoma (TC) and thymoma (T). Taking advantage of the French RYTHMIC network prospective database, we investigated the off-label efficacy of sunitinib in previously-treated thymic epithelial tumors (TETs) patients not included in a clinical trial. METHODS: RYTHMIC database started in 2012, and prospectively collects clinical, imaging, treatment, and follow-up data of all patients diagnosed with TET, for whom management is discussed at a national multidisciplinary tumor board. All patients who received sunitinib were selected for this analysis. RESULTS: 28 patients from 7 institutions were identified, including 20 TC and 8T; 32% of patients were females, and median age was 50 years. Fifteen patients (54%) received sunitinib as ≥4th line treatment. The initial daily dose of sunitinib was 50mg in 11 patients, 37.5mg in 16 patients and 25mg in 1 patient. Sunitinib adverse events were all manageable and tolerable; 8 patients had to stop sunitinib due to toxicity after a median duration of treatment of 2.7 months. In the overall population, disease control rate was of 63% (86% for T, and 55% for TC); overall response rate was 22% (29% for T, and 20% for TC). Median PFS in the whole population was 3.7 months (5.4 months for T, and 3.3 months for TC, p=0.097). The median overall survival in the whole population was 15.4 months: survival was not reached for T, and was 12.3 months for TC patients (p=0.043). CONCLUSION:Sunitinib is an active treatment in TETs irrespective of histological subtype, supporting the use of tyrosine kinase inhibitors with anti-angiogenic activity as alternative treatment options in refractory disease.
Authors: Luis Cabezón-Gutiérrez; Parham Khosravi-Shahi; Sara Custodio-Cabello; Maria García-Martos; Magda Palka-Kotlowska; Ana Isabel Franco-Moreno Journal: Cureus Date: 2018-07-14
Authors: Gabrielle Drevet; Stéphane Collaud; François Tronc; Nicolas Girard; Jean-Michel Maury Journal: Cancer Manag Res Date: 2019-07-22 Impact factor: 3.989
Authors: Isabelle Rouquette; Estelle Taranchon-Clermont; Julia Gilhodes; Maria-Virginia Bluthgen; Romain Perallon; Lara Chalabreysse; Anne De Muret; Veronique Hofman; Alexander Marx; Marie Parrens; Veronique Secq; Vincent Thomas de Montpreville; Françoise Galateau-Salle; Pierre Brousset; Julie Milia; Nicolas Girard; Benjamin Besse; Thierry Jo Molina; Julien Mazières Journal: Biomark Res Date: 2019-12-04