| Literature DB >> 27236860 |
Charlotte Lässig1, Karl-Peter Hopfner2.
Abstract
RIG-I-like receptors detect cytosolic viral RNA and activate an antiviral innate immune response. A new study employs the one STrEP-purification technique and next generation sequencing to characterize physiological ligands in an infected cell. The view of all three RLRs bound to viral RNAs shows specialization, collaboration and new binding sites.Keywords: LGP2; MDA5; RIG-I; RNA; affinity purification; innate immune system; next generation sequencing
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Year: 2016 PMID： 27236860 DOI： 10.1016/j.tim.2016.05.001
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079