Yoo Jin Hong1, Tai Kyung Kim2, Donghyun Hong3, Chul Hwan Park4, Sae Jong Yoo2, Mary Ellen Wickum1, Jin Hur1, Hye-Jeong Lee1, Young Jin Kim1, Young Joo Suh1, Andreas Greiser5, Mun Young Paek6, Byoung Wook Choi7. 1. Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. 2. Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Korea. 3. Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany. 4. Department of Radiology and Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. 5. Siemens AG Healthcare, Erlangen, Germany. 6. Siemens Ltd., Seoul, Korea. 7. Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: bchoi@yuhs.ac.
Abstract
OBJECTIVES: This study sought to evaluate whether patterns of myocardial change in doxorubicin-induced dilated cardiomyopathy determined using dual-energy computed tomography (CT) were similar to characterization by extracellular volume fraction (ECV) using cardiac magnetic resonance (CMR) T1-mapping and collagen volume fraction (CVF) measured using histology. BACKGROUND: Anthracycline chemoagents are effective against a wide range of malignant conditions. However, cardiotoxicity is a well-known adverse effect of these drugs. Dual-energy CT could be as useful as magnetic resonance (MR) to evaluate myocardial change in anthracycline-induced cardiotoxicity. METHODS: A dilated cardiomyopathy rabbit model was generated by injecting 11 adult New Zealand rabbits with 1.0 mg/kg of doxorubicin twice weekly for 16 weeks. Contrast-enhanced dual-energy CT and pre-contrast and post-contrast T1-mapping CMR using a prototype modified Look-Locker inversion recovery on a clinical 3-T scanner were performed on 15 rabbits, including 4 control animals, to calculate ECV at baseline, and at 6, 12, and 16 weeks after doxorubicin administration. RESULTS: The mean ECV values (%) on CT and CMR at 6, 12, and 16 weeks after modeling were significantly higher than those measured at baseline (CT ECV: 35.3%, 41.9%, 42.1% vs. 28.5%; MR ECV: 32.6%, 35.8%, 41.3% vs. 28.8%, respectively; all p < 0.001). CT ECV and MR ECV values were well correlated (r = 0.888; p < 0.001). Both were well correlated with CVF on histology (CT ECV vs. CVF, r = 0.925, p < 0.001 and MR ECV vs. CVF, r = 0.961, p < 0.001, respectively). CONCLUSIONS: Dual-energy CT ECV correlated well with CMR and histology. Dual-energy CT is useful for characterizing doxorubicin-induced cardiomyopathy by measuring ECV fraction; however, further technical improvements are desirable to lower motion artifact and improve image quality of the iodine map.
OBJECTIVES: This study sought to evaluate whether patterns of myocardial change in doxorubicin-induced dilated cardiomyopathy determined using dual-energy computed tomography (CT) were similar to characterization by extracellular volume fraction (ECV) using cardiac magnetic resonance (CMR) T1-mapping and collagen volume fraction (CVF) measured using histology. BACKGROUND:Anthracycline chemoagents are effective against a wide range of malignant conditions. However, cardiotoxicity is a well-known adverse effect of these drugs. Dual-energy CT could be as useful as magnetic resonance (MR) to evaluate myocardial change in anthracycline-induced cardiotoxicity. METHODS: A dilated cardiomyopathyrabbit model was generated by injecting 11 adult New Zealand rabbits with 1.0 mg/kg of doxorubicin twice weekly for 16 weeks. Contrast-enhanced dual-energy CT and pre-contrast and post-contrast T1-mapping CMR using a prototype modified Look-Locker inversion recovery on a clinical 3-T scanner were performed on 15 rabbits, including 4 control animals, to calculate ECV at baseline, and at 6, 12, and 16 weeks after doxorubicin administration. RESULTS: The mean ECV values (%) on CT and CMR at 6, 12, and 16 weeks after modeling were significantly higher than those measured at baseline (CT ECV: 35.3%, 41.9%, 42.1% vs. 28.5%; MR ECV: 32.6%, 35.8%, 41.3% vs. 28.8%, respectively; all p < 0.001). CT ECV and MR ECV values were well correlated (r = 0.888; p < 0.001). Both were well correlated with CVF on histology (CT ECV vs. CVF, r = 0.925, p < 0.001 and MR ECV vs. CVF, r = 0.961, p < 0.001, respectively). CONCLUSIONS: Dual-energy CT ECV correlated well with CMR and histology. Dual-energy CT is useful for characterizing doxorubicin-induced cardiomyopathy by measuring ECV fraction; however, further technical improvements are desirable to lower motion artifact and improve image quality of the iodine map.
Authors: Rolf Symons; Tyler E Cork; Manu N Lakshmanan; Robert Evers; Cynthia Davies-Venn; Kelly A Rice; Marvin L Thomas; Chia-Ying Liu; Steffen Kappler; Stefan Ulzheimer; Veit Sandfort; David A Bluemke; Amir Pourmorteza Journal: Int J Cardiovasc Imaging Date: 2017-03-13 Impact factor: 2.357
Authors: Vidhya Kumar; Kevin E McElhanon; James K Min; Xin He; Zhaobin Xu; Eric X Beck; Orlando P Simonetti; Noah Weisleder; Subha V Raman Journal: J Cardiovasc Comput Tomogr Date: 2017-12-05
Authors: Yoo Jin Hong; Heae Surng Park; Jeffrey Kihyun Park; Kyunghwa Han; Chul Hwan Park; Tai Kyung Kim; Sae Jong Yoo; Ji Yeon Lee; Pan Ki Kim; Jin Hur; Hye-Jeong Lee; Young Jin Kim; Young Joo Suh; Mun Young Paek; Byoung Wook Choi Journal: Sci Rep Date: 2017-06-01 Impact factor: 4.379