Ceyda Tuna Kirsaclioglu1, Bahar Çuhacı Çakır2, Gulsah Bayram3, Fatih Akbıyık4, Pamir Işık5, Bahattin Tunç5. 1. Department of Pediatric Gastroenterology, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey. ceytun@yahoo.com. 2. Well Child Clinic, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey. 3. Department of Radiology, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey. 4. Department of Pediatric Surgery, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey. 5. Department of Pediatric Hematology, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey.
Abstract
AIM: The aim of this study was to evaluate the clinical presentation, risk factors, complications, treatment and outcomes of cholelithiasis in children. METHODS: Children with cholelithiasis were reviewed for demographic information, predisposing factors, presenting symptoms, laboratory findings, complications, treatment and outcome, retrospectively. RESULTS: A total of 254 children with cholelithiasis (mean age: 8.9 ± 5.2 years) were recruited to the study. Girls (52.8%) were significantly older than boys (P < 0.001). Symptomatic patients (59%) were significantly older than asymptomatic patients (P = 0.002). Abdominal pain was the most frequent symptom. No risk factors were identified in 56.6% of the patients. Ceftriaxone (20%) was the most commonly associated risk factor. At presentation, at least one of the following complications was seen in 14.1% of patients: cholecystitis (10.9%), obstructive jaundice (2.7%), pancreatitis (1.96%) and cholangitis (1.2%). There was no relationship between gallstone size and symptoms, aetiological factors and complications. The cholelithiasis dissolution rate was higher in younger children (P = 0.032), in those with biliary sludge (P < 0.0001) and ceftriaxone-related cholelithiasis (P < 0.001). Haemolytic anaemia (P = 0.001) and older age (P = 0.002) were associated with stable stones. Ursodeoxycholic acid was administered to 94.4% of patients at presentation. Twenty-nine patients underwent cholecystectomy, and seven patients underwent endoscopic retrograde cholangiopancreotography. Patients who were symptomatic at presentation had significantly more frequent symptoms at follow-up (P < 0.001) CONCLUSIONS: Dissolution rate of cholelithiasis was higher in younger children, biliary sludge formation and ceftriaxone-related cholelithiasis but lower in older children and haemolytic anaemia-related cholelithiasis.
AIM: The aim of this study was to evaluate the clinical presentation, risk factors, complications, treatment and outcomes of cholelithiasis in children. METHODS:Children with cholelithiasis were reviewed for demographic information, predisposing factors, presenting symptoms, laboratory findings, complications, treatment and outcome, retrospectively. RESULTS: A total of 254 children with cholelithiasis (mean age: 8.9 ± 5.2 years) were recruited to the study. Girls (52.8%) were significantly older than boys (P < 0.001). Symptomatic patients (59%) were significantly older than asymptomatic patients (P = 0.002). Abdominal pain was the most frequent symptom. No risk factors were identified in 56.6% of the patients. Ceftriaxone (20%) was the most commonly associated risk factor. At presentation, at least one of the following complications was seen in 14.1% of patients: cholecystitis (10.9%), obstructive jaundice (2.7%), pancreatitis (1.96%) and cholangitis (1.2%). There was no relationship between gallstone size and symptoms, aetiological factors and complications. The cholelithiasis dissolution rate was higher in younger children (P = 0.032), in those with biliary sludge (P < 0.0001) and ceftriaxone-related cholelithiasis (P < 0.001). Haemolytic anaemia (P = 0.001) and older age (P = 0.002) were associated with stable stones. Ursodeoxycholic acid was administered to 94.4% of patients at presentation. Twenty-nine patients underwent cholecystectomy, and seven patients underwent endoscopic retrograde cholangiopancreotography. Patients who were symptomatic at presentation had significantly more frequent symptoms at follow-up (P < 0.001) CONCLUSIONS: Dissolution rate of cholelithiasis was higher in younger children, biliary sludge formation and ceftriaxone-related cholelithiasis but lower in older children and haemolytic anaemia-related cholelithiasis.
Authors: Charles Newton Odongo; Carlos Cabrera Dreque; David Mutiibwa; Felix Bongomin; Felix Oyania; Mvuyo Maqhawe Sikhondze; Moses Acan; Raymond Atwine; Fred Kirya; Martin Situma Journal: Clin Exp Gastroenterol Date: 2022-06-11
Authors: Kathleen J Motil; Jane B Lane; Judy O Barrish; Fran Annese; Suzanne Geerts; Lauren McNair; Steven A Skinner; Jeffrey L Neul; Daniel G Glaze; Alan K Percy Journal: J Pediatr Gastroenterol Nutr Date: 2019-06 Impact factor: 2.839