Béatrice Husson1, Lucie Hertz-Pannier2, Catherine Adamsbaum3, Cyrille Renaud4, Emilie Presles5, Mickael Dinomais6, Manoelle Kossorotoff7, Pierre Landrieu8, Stéphane Chabrier9. 1. AP-HP, Paediatric Radiology Dpt., French Centre for Paediatric Stroke, Bicêtre Hospital, 78 rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France. 2. Paris Descartes University, INSERM U663, Paris-France/Neurospin, I2BM, DSV, CEA, Orsay, France. 3. Paris-Sud University, Faculty of Medicine, 63 rue Gabriel Péri/AP-HP, Pediatric Radiology Dpt, Bicêtre Hospital, 78 rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France. Electronic address: adamsbaum.catherine@gmail.com. 4. Department of Paediatric Physical Medicine and Rehabilitation, French Centre for Paediatric Stroke, St-Étienne Hospital, France. 5. INSERM & University of Lyon/St Etienne, Dysfonction vasculaire et hémostase (DVA) Team, U1090 Sainbiose, St. Etienne, France. 6. LUNAM, Paediatric Physical Medicine and Rehabilitation Dpt, Angers Hospital, 49933 Angers, France, France. 7. Paris-Descartes University, Faculty of Medicine/AP-HP, French Centre for Paediatric Stroke, Paediatric Neurology Dpt., Necker-Enfants Malades Hospital, 149 rue de Sevres, 75015 Paris, France. 8. AP-HP, Pediatric Neurology Dpt., Bicêtre Hospital, 78 rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France. 9. Department of Paediatric Physical Medicine and Rehabilitation, French Centre for Paediatric Stroke, St-Étienne Hospital, France; INSERM & University of Lyon/St Etienne, Dysfonction vasculaire et hémostase (DVA) Team, U1090 Sainbiose, St. Etienne, France.
Abstract
AIM: Neonatal arterial ischemic stroke (NAIS) results from a focal disruption of the blood flow in a cerebral artery by a not well understood mechanism. Our objective is to describe the acute MRangiography (MRA) findings in infants with an NAIS in the middle cerebral artery (MCA) territory and correlate them with early parenchymal infarcts and motor outcome. METHODS: Among one hundred prospectively followed neonates with NAIS, we studied thirty-seven patients with an MCA infarct explored with circle of Willis MRA. MCA flow characteristics were documented, along with infarct location/extent and motor outcome at age 7 years. RESULTS: Twenty-three (62%) of the children showed arterial changes, all ipsilateral to the NAIS, with occlusion in six, thrombus-type flow defect in nine, and unilateral increased flow in enlarged insular arteries in the remaining eight. There was a statistically significant correlation between parenchymal and arterial MR findings (p=0.0002). A normal MRA had a negative predictive value of 100% (95% CI: 76.8-100) in ruling out a main branch infarct. Patients with abnormal MRA tended to be at increased risk for cerebral palsy (OR=3.1). Occlusion was associated with a worse outcome (p=0.04). INTERPRETATION: MRangiography shows arterial abnormalities suggesting that embolism is a frequent cause of NAIS.
AIM: Neonatal arterial ischemic stroke (NAIS) results from a focal disruption of the blood flow in a cerebral artery by a not well understood mechanism. Our objective is to describe the acute MRangiography (MRA) findings in infants with an NAIS in the middle cerebral artery (MCA) territory and correlate them with early parenchymal infarcts and motor outcome. METHODS: Among one hundred prospectively followed neonates with NAIS, we studied thirty-seven patients with an MCA infarct explored with circle of Willis MRA. MCA flow characteristics were documented, along with infarct location/extent and motor outcome at age 7 years. RESULTS: Twenty-three (62%) of the children showed arterial changes, all ipsilateral to the NAIS, with occlusion in six, thrombus-type flow defect in nine, and unilateral increased flow in enlarged insular arteries in the remaining eight. There was a statistically significant correlation between parenchymal and arterial MR findings (p=0.0002). A normal MRA had a negative predictive value of 100% (95% CI: 76.8-100) in ruling out a main branch infarct. Patients with abnormal MRA tended to be at increased risk for cerebral palsy (OR=3.1). Occlusion was associated with a worse outcome (p=0.04). INTERPRETATION: MRangiography shows arterial abnormalities suggesting that embolism is a frequent cause of NAIS.