Fa-Jin Dong1, Jin-Feng Xu2, Dong Du3, Yang Jiao1, Lei Zhang1, Min Li4, Hui-Yu Liu1, Yi Xiong1, Hui Luo1. 1. Department of Ultrasonography, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China. 2. Department of Ultrasonography, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China. Electronic address: xujinfeng@yahoo.com. 3. Department of Hand and Microvascular Surgery, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China. Electronic address: 13713807676@163.com. 4. Department of Personnel, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China.
Abstract
OBJECTIVE: To examine whether dynamic 3D contrast-enhanced ultrasound (CEUS) is superior to 2D imaging in revealing vascularization of focal liver lesions (FLLs). METHODS: Dynamic 2D and 3D CEUS were used to assess the vascularity of FLLs in 83 patients. The two analyses were carried out sequentially following a bolus intravenous injection of SonoVue contrast agent, one injection of 1.5-2mL was given for each part of the study (one for the 2D and another for the 3D). Due to the large data volume for 3D analysis, only the arterial phase (20-25s) was recorded and analyzed. The data were analyzed by two independent analysts. RESULTS: The current study included a total of 83 patients with FLL. The diagnosis was established based on histopathology, Computed Tomography (CT), and magnetic resonance imaging (MRI). Among the 83 cases, 61 were hepatocellular carcinomas (include 10 metastasis, 51 HCCs), and the remaining 22 were benign lesions: hemangiomas (n=15), focal nodular hyperplasias (n=4), and inflammatory lesions (n=3). The overall analysis showed similar patterns of enhancement between the 2D and 3D CEUS in the following features: morphological characteristics, and spatial relationships. In comparison to 2D imaging, 3D CEUS reveal more details of the boundary and feeding arteries of the lesions, as well as distorted features of supply vessels of hepatocellular carcinomas. CONCLUSIONS: Dynamic 3D-CEUS is superior to 2D-CEUS in displaying the spatial relationship of FLLs and their vascularity patterns, and simultaneous imaging of FLL perfusion and anatomic features.
OBJECTIVE: To examine whether dynamic 3D contrast-enhanced ultrasound (CEUS) is superior to 2D imaging in revealing vascularization of focal liver lesions (FLLs). METHODS: Dynamic 2D and 3D CEUS were used to assess the vascularity of FLLs in 83 patients. The two analyses were carried out sequentially following a bolus intravenous injection of SonoVue contrast agent, one injection of 1.5-2mL was given for each part of the study (one for the 2D and another for the 3D). Due to the large data volume for 3D analysis, only the arterial phase (20-25s) was recorded and analyzed. The data were analyzed by two independent analysts. RESULTS: The current study included a total of 83 patients with FLL. The diagnosis was established based on histopathology, Computed Tomography (CT), and magnetic resonance imaging (MRI). Among the 83 cases, 61 were hepatocellular carcinomas (include 10 metastasis, 51 HCCs), and the remaining 22 were benign lesions: hemangiomas (n=15), focal nodular hyperplasias (n=4), and inflammatory lesions (n=3). The overall analysis showed similar patterns of enhancement between the 2D and 3D CEUS in the following features: morphological characteristics, and spatial relationships. In comparison to 2D imaging, 3D CEUS reveal more details of the boundary and feeding arteries of the lesions, as well as distorted features of supply vessels of hepatocellular carcinomas. CONCLUSIONS: Dynamic 3D-CEUS is superior to 2D-CEUS in displaying the spatial relationship of FLLs and their vascularity patterns, and simultaneous imaging of FLL perfusion and anatomic features.
Authors: Christoph F Dietrich; Michalakis Averkiou; Michael Bachmann Nielsen; Richard G Barr; Peter N Burns; Fabrizio Calliada; Vito Cantisani; Byung Choi; Maria C Chammas; Dirk-André Clevert; Michel Claudon; Jean-Michel Correas; Xin-Wu Cui; David Cosgrove; Mirko D'Onofrio; Yi Dong; JohnR Eisenbrey; Teresa Fontanilla; Odd Helge Gilja; Andre Ignee; Christian Jenssen; Yuko Kono; Masatoshi Kudo; Nathalie Lassau; Andrej Lyshchik; Maria Franca Meloni; Fuminori Moriyasu; Christian Nolsøe; Fabio Piscaglia; Maija Radzina; Adrian Saftoiu; Paul S Sidhu; Ioan Sporea; Dagmar Schreiber-Dietrich; Claude B Sirlin; Maria Stanczak; Hans-Peter Weskott; Stephanie R Wilson; Juergen Karl Willmann; Tae Kyoung Kim; Hyun-Jung Jang; Alexandar Vezeridis; Sue Westerway Journal: Ultrasound Int Open Date: 2018-02-07
Authors: Ahmed El Kaffas; Rosa Maria Silveira Sigrist; George Fisher; Sunitha Bachawal; Joy Liau; Huaijun Wang; Alexander Karanany; Isabelle Durot; Jarrett Rosenberg; Dimitre Hristov; Jürgen K Willmann Journal: Theranostics Date: 2017-08-23 Impact factor: 11.556