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Literature DB >> 27235342

Antibodies to myelin basic protein are associated with cognitive decline after stroke.

Kyra J Becker¹, Patricia Tanzi², Dannielle Zierath², Marion S Buckwalter³.

Abstract

B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).

Entities: Chemical Disease Gene Species

Keywords: Autoimmune; Cognitive decline; MBP antibodies; Stroke

Mesh：

Substances：

Year: 2016 PMID： 27235342 PMCID： PMC4884610 DOI： 10.1016/j.jneuroim.2016.04.001

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

11 in total

1. Antibodies to brain antigens following stroke.

Authors: N M Bornstein; B Aronovich; A D Korczyn; S Shavit; D M Michaelson; J Chapman
Journal: Neurology Date: 2001-02-27 Impact factor: 9.910

2. Trajectory of Cognitive Decline After Incident Stroke.

Authors: Deborah A Levine; Andrzej T Galecki; Kenneth M Langa; Frederick W Unverzagt; Mohammed U Kabeto; Bruno Giordani; Virginia G Wadley
Journal: JAMA Date: 2015-07-07 Impact factor: 56.272

3. Myelin basic protein autoantibodies, white matter disease and stroke outcome.

Authors: Dean Shibata; Kevin Cain; Patricia Tanzi; Dannielle Zierath; Kyra Becker
Journal: J Neuroimmunol Date: 2012-08-29 Impact factor: 3.478

4. Autoimmune responses to the brain after stroke are associated with worse outcome.

Authors: Kyra J Becker; Angela J Kalil; Pat Tanzi; Dannielle K Zierath; Anna V Savos; J Michael Gee; Jessica Hadwin; Kelly T Carter; Dean Shibata; Kevin C Cain
Journal: Stroke Date: 2011-07-28 Impact factor: 7.914

5. B-lymphocyte-mediated delayed cognitive impairment following stroke.

Authors: Kristian P Doyle; Lisa N Quach; Montse Solé; Robert C Axtell; Thuy-Vi V Nguyen; Gilberto J Soler-Llavina; Sandra Jurado; Jullet Han; Lawrence Steinman; Frank M Longo; Julie A Schneider; Robert C Malenka; Marion S Buckwalter
Journal: J Neurosci Date: 2015-02-04 Impact factor: 6.167

6. Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia.

Authors: Arthur Liesz; Stefan Roth; Markus Zorn; Li Sun; Kerstin Hofmann; Roland Veltkamp
Journal: Exp Neurol Date: 2015-05-07 Impact factor: 5.330

7. Dementia after stroke: the Framingham Study.

Authors: Cristina S Ivan; Sudha Seshadri; Alexa Beiser; Rhoda Au; Carlos S Kase; Margaret Kelly-Hayes; Philip A Wolf
Journal: Stroke Date: 2004-04-29 Impact factor: 7.914

8. Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke.

Authors: Svetlana A Dambinova; Guerman A Khounteev; Galina A Izykenova; Igor G Zavolokov; Anna Y Ilyukhina; Alexander A Skoromets
Journal: Clin Chem Date: 2003-10 Impact factor: 8.327

9. Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size.

Authors: Maggie L Kalev-Zylinska; Wymond Symes; Kevin C E Little; Peng Sun; Daying Wen; Linzi Qiao; Deborah Young; Matthew J During; P Alan Barber
Journal: Stroke Date: 2013-05-30 Impact factor: 7.914

Review 10. Antigen Presentation After Stroke.

Authors: Francesc Miró-Mur; Xabier Urra; Mattia Gallizioli; Angel Chamorro; Anna M Planas
Journal: Neurotherapeutics Date: 2016-10 Impact factor: 7.620

Antibodies to myelin basic protein are associated with cognitive decline after stroke.

1. Antibodies to brain antigens following stroke.

2. Trajectory of Cognitive Decline After Incident Stroke.

3. Myelin basic protein autoantibodies, white matter disease and stroke outcome.

4. Autoimmune responses to the brain after stroke are associated with worse outcome.

5. B-lymphocyte-mediated delayed cognitive impairment following stroke.

6. Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia.

7. Dementia after stroke: the Framingham Study.

8. Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke.

9. Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size.

10. Incidence of dementia after ischemic stroke: results of a longitudinal study.

Review 1. Executive (dys)function after stroke: special considerations for behavioral pharmacology.

2. Stroke, Inflammation and the Immune Response: Dawn of a New Era.

Review 3. Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?

4. High-Throughput Profiling of Circulating Antibody Signatures for Stroke Diagnosis Using Small Volumes of Whole Blood.

Review 5. The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development.

6. Role of B cells and the aging brain in stroke recovery and treatment.

Review 7. Immune responses to stroke: mechanisms, modulation, and therapeutic potential.

Review 8. Immunological mechanisms in poststroke dementia.

Review 9. Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.

Review 10. Antigen Presentation After Stroke.