Y Kihara1, Y Nakamura2, T Yokoyama2, O Konno2, H Iwamoto2, S Kawachi2. 1. Department of Digestive and Transplantation Surgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan. Electronic address: yukihara7@hotmail.co.jp. 2. Department of Digestive and Transplantation Surgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.
Abstract
BACKGROUND: To increase the number of cadaveric kidney transplants in Japan, it is necessary to proactively perform transplantation from marginal donors. We had the opportunity to frequently perform kidney transplantation from expanded-criteria donors (ECDs), and it is anticipated that there will be increases in the number of ECD kidney transplants. METHODS: In our institution, 18 patients underwent cadaveric kidney transplantation from January 2001 to December 2011. Sixteen of those patients were classified into 2 groups according to donation after brain death (BD) or after cardiac death (CD). We also classified donors as ECDs or standard-criteria donors (SCDs). RESULTS: Kidney graft survival and engraftment were observed in all of the patients. Renal function at 1 year after transplantation was significantly better in the BD group than in the CD group. However, there was no significant difference between the groups in renal function at 3 and 5 years. Renal function at 1 and 3 years after transplantation was significantly better in the SCD group than in the ECD group, but there was no difference in renal function between the SDC and ECD groups at 5 years. CONCLUSIONS: The results were good for all of the patients. There are many reports that graft survival rate at 3-5 years after transplantation from ECDs is poorer than from SCDs. However, no statistically significant difference was found in kidney function at ≥5 years between the ECD and SCD groups in our patients.
BACKGROUND: To increase the number of cadaveric kidney transplants in Japan, it is necessary to proactively perform transplantation from marginal donors. We had the opportunity to frequently perform kidney transplantation from expanded-criteria donors (ECDs), and it is anticipated that there will be increases in the number of ECD kidney transplants. METHODS: In our institution, 18 patients underwent cadaveric kidney transplantation from January 2001 to December 2011. Sixteen of those patients were classified into 2 groups according to donation after brain death (BD) or after cardiac death (CD). We also classified donors as ECDs or standard-criteria donors (SCDs). RESULTS: Kidney graft survival and engraftment were observed in all of the patients. Renal function at 1 year after transplantation was significantly better in the BD group than in the CD group. However, there was no significant difference between the groups in renal function at 3 and 5 years. Renal function at 1 and 3 years after transplantation was significantly better in the SCD group than in the ECD group, but there was no difference in renal function between the SDC and ECD groups at 5 years. CONCLUSIONS: The results were good for all of the patients. There are many reports that graft survival rate at 3-5 years after transplantation from ECDs is poorer than from SCDs. However, no statistically significant difference was found in kidney function at ≥5 years between the ECD and SCD groups in our patients.
Authors: M Kumaresan; A Sangeetha; P K Sankaran; Gunapriya Raghunath; Balaji Karunakaran; Yuvaraj Maria Francis; T Siva; J Vijayakumar; Madhan Krishnan Journal: Bioinformation Date: 2021-07-31