| Literature DB >> 27234504 |
Yi Zhang1, Hai-Yang Yu1, Li-Ping Chao2, Lu Qu1, Jing-Ya Ruan2, Yan-Xia Liu1, Yong-Zhe Dong2, Li-Feng Han2, Tao Wang3.
Abstract
Seven new steroid glycosides, dioscorosides A1 (1), A2 (2), B1 (3), B2 (4), C1 (5), C2 (6), and D (7), together with 22 known ones (8-29) were isolated from the rhizomes of Dioscorea septemloba, their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages. Among them, spirostane glycosides 18 and 21-24 exhibited significant inhibition of nitrite production. Moreover, the structure-activity relationship was summarized.Entities:
Keywords: Anti-inflammatory activity; Dioscorea septemloba Thunb; Steroids
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Year: 2016 PMID： 27234504 DOI： 10.1016/j.steroids.2016.05.007
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668