Literature DB >> 27233084

The utilization of spirocyclic scaffolds in novel drug discovery.

Ya-Jun Zheng1, Colin M Tice1.   

Abstract

Keywords:  Drug discovery; spirocycles; spirocyclic scaffolds; structure-based drug design

Mesh：

Substances：

Year:  2016        PMID： 27233084     DOI： 10.1080/17460441.2016.1195367

Source DB:  PubMed          Journal:  Expert Opin Drug Discov        ISSN： 1746-0441            Impact factor:   6.098


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  21 in total

1.  Synthesis of thia- and thioxo-tetraazaspiro[4.4]nonenones from nitrile imines and arylidenethiohydantoins.

Authors:  Issa Yavari; Zohreh Taheri; Sara Sheikhi; Samira Bahemmat; Mohammad R Halvagar
Journal:  Mol Divers       Date:  2020-02-25       Impact factor: 2.943

2.  Catalytic Arylboration of Spirocyclic Cyclobutenes: Rapid Access to Highly Substituted Spiro[3.n]alkanes.

Authors:  Amit Kumar Simlandy; Mao-Yun Lyu; M Kevin Brown
Journal:  ACS Catal       Date:  2021-10-06       Impact factor: 13.700

3.  Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones.

Authors:  Jasper L Tyler; Adam Noble; Varinder K Aggarwal
Journal:  Angew Chem Int Ed Engl       Date:  2021-04-16       Impact factor: 15.336

4.  Construction of NH-Unprotected Spiropyrrolidines and Spiroisoindolines by [4+1] Cyclizations of γ-Azidoboronic Acids with Cyclic N-Sulfonylhydrazones.

Authors:  Lucía López; María-Paz Cabal; Carlos Valdés
Journal:  Angew Chem Int Ed Engl       Date:  2021-11-25       Impact factor: 16.823

5.  Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines.

Authors:  Benjamin R Lichman; Jianxiong Zhao; Helen C Hailes; John M Ward
Journal:  Nat Commun       Date:  2017-04-03       Impact factor: 14.919

Review 6.  Synthesis of spirocyclic scaffolds using hypervalent iodine reagents.

Authors:  Fateh V Singh; Priyanka B Kole; Saeesh R Mangaonkar; Samata E Shetgaonkar
Journal:  Beilstein J Org Chem       Date:  2018-07-17       Impact factor: 2.883

7.  Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol.

Authors:  Natarajan Arumugam; Abdulrahman I Almansour; Raju Suresh Kumar; Dhaifallah M Al-Thamili; Govindasami Periyasami; V S Periasamy; Jegan Athinarayanan; Ali A Alshatwi; S M Mahalingam; J Carlos Menéndez
Journal:  Chem Cent J       Date:  2018-09-01       Impact factor: 4.215

8.  Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.

Authors:  Thomas A King; Hannah L Stewart; Kim T Mortensen; Andrew J P North; Hannah F Sore; David R Spring
Journal:  European J Org Chem       Date:  2019-07-29

9.  Fluorescent "Turn-Off" Detection of Fluoride and Cyanide Ions Using Zwitterionic Spirocyclic Meisenheimer Compounds.

Authors:  Marina Benet; Marc Villabona; Carles Llavina; Silvia Mena; Jordi Hernando; Rabih O Al-Kaysi; Gonzalo Guirado
Journal:  Molecules       Date:  2017-10-27       Impact factor: 4.411

10.  Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines.

Authors:  Giulia Rainoldi; Matteo Faltracco; Claudia Spatti; Alessandra Silvani; Giordano Lesma
Journal:  Molecules       Date:  2017-11-21       Impact factor: 4.411
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