Claudio Borghi1, Florence Tubach2, Guy De Backer3, Jean Dallongeville4, Eliseo Guallar5, Jesús Medina6, Joep Perk7, Carine Roy8, José R Banegas9, Fernando Rodriguez-Artalejo9, Julian P Halcox10. 1. Department of Internal Medicine, Ageing and Clinical Nephrology, University of Bologna, Bologna, Italy. Electronic address: claudio.borghi@unibo.it. 2. INSERM CIC-EC 1425 and Département d'Epidemiologie et Recherche Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France; Université Paris Diderot, UMR 1123, ECEVE, Paris, France. 3. Department of Public Health, University of Ghent, Ghent, Belgium. 4. INSERM U 744, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France. 5. Departments of Epidemiology and Medicine and Welch Center of Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Research, Madrid, Spain. 6. Medical Evidence and Observational Research, AstraZeneca, Madrid, Spain. 7. Faculty of Health and Caring Sciences, Linnaeus University, Kalmar, Sweden. 8. INSERM CIC-EC 1425 and Département d'Epidemiologie et Recherche Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France. 9. Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/IdiPaz and CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. 10. Institute of Life Sciences 2, Swansea University College of Medicine, Swansea, UK.
Abstract
BACKGROUND: The prevalence of and factors associated with uncontrolled hypertension and apparent resistant hypertension were assessed in the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA; NCT00882336). METHODS: EURIKA was a cross-sectional observational study including patients being treated for the primary prevention of cardiovascular disease in 12 European countries. Patients were assessed if they were being treated for hypertension (N=5220). Blood pressure control was defined according to European guidelines, with sensitivity analysis taking account of patients' age and diabetes status. Associated factors were assessed using multivariate analysis. RESULTS: In the primary analysis, a total of 2691 patients (51.6%) had uncontrolled hypertension. Factors significantly associated with an increased risk of having uncontrolled hypertension included female sex (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.93-2.73), body mass index (BMI; OR per kg/m(2): 1.03; 95% CI: 1.01-1.04), and geographic location. A total of 749 patients (14.3%) had apparent resistant hypertension. Factors significantly associated with an increased risk of having apparent resistant hypertension included BMI (OR per kg/m(2): 1.06; 95% CI: 1.04-1.08), diabetes (OR: 1.28; 95% CI: 1.06-1.53), use of statins (OR: 1.36; 95% CI: 1.15-1.62), serum uric acid levels (OR: 1.16; 95% CI: 1.09-1.23), and geographic location. Similar results were seen in sensitivity analyses. CONCLUSIONS: Over 50% of patients treated for hypertension continued to have uncontrolled blood pressure and 14.3% had apparent resistant hypertension. Positive associations were seen with other cardiovascular risk factors.
RCT Entities:
BACKGROUND: The prevalence of and factors associated with uncontrolled hypertension and apparent resistant hypertension were assessed in the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA; NCT00882336). METHODS: EURIKA was a cross-sectional observational study including patients being treated for the primary prevention of cardiovascular disease in 12 European countries. Patients were assessed if they were being treated for hypertension (N=5220). Blood pressure control was defined according to European guidelines, with sensitivity analysis taking account of patients' age and diabetes status. Associated factors were assessed using multivariate analysis. RESULTS: In the primary analysis, a total of 2691 patients (51.6%) had uncontrolled hypertension. Factors significantly associated with an increased risk of having uncontrolled hypertension included female sex (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.93-2.73), body mass index (BMI; OR per kg/m(2): 1.03; 95% CI: 1.01-1.04), and geographic location. A total of 749 patients (14.3%) had apparent resistant hypertension. Factors significantly associated with an increased risk of having apparent resistant hypertension included BMI (OR per kg/m(2): 1.06; 95% CI: 1.04-1.08), diabetes (OR: 1.28; 95% CI: 1.06-1.53), use of statins (OR: 1.36; 95% CI: 1.15-1.62), serum uric acid levels (OR: 1.16; 95% CI: 1.09-1.23), and geographic location. Similar results were seen in sensitivity analyses. CONCLUSIONS: Over 50% of patients treated for hypertension continued to have uncontrolled blood pressure and 14.3% had apparent resistant hypertension. Positive associations were seen with other cardiovascular risk factors.
Authors: F Fici; G Seravalle; N Koylan; I Nalbantgil; N Cagla; Y Korkut; F Quarti-Trevano; W Makel; G Grassi Journal: High Blood Press Cardiovasc Prev Date: 2017-05-11
Authors: W A Santos; K M C Dourado; F A Araújo; R L C Jesus; R A Moraes; S C D S Oliveira; Q L Alves; L O Simões; L L Casais-E-Silva; R S Costa; E S Velozo; D F Silva Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2020-10-09 Impact factor: 3.000
Authors: Robert M Carey; David A Calhoun; George L Bakris; Robert D Brook; Stacie L Daugherty; Cheryl R Dennison-Himmelfarb; Brent M Egan; John M Flack; Samuel S Gidding; Eric Judd; Daniel T Lackland; Cheryl L Laffer; Christopher Newton-Cheh; Steven M Smith; Sandra J Taler; Stephen C Textor; Tanya N Turan; William B White Journal: Hypertension Date: 2018-11 Impact factor: 10.190
Authors: Francisco Flavio Costa Filho; Ari Timerman; Jose Francisco Kerr Saraiva; Carlos Costa Magalhaes; Ibraim Masciarelli F Pinto; Gustavo B F Oliveira; Antonio Cordeiro Mattos; Alvaro Avezum Journal: J Clin Hypertens (Greenwich) Date: 2017-11-23 Impact factor: 3.738