Literature DB >> 27232281

Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile.

Bin Wang1, Liang Chen1, Hao-Teng Chang2,3.   

Abstract

Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.

Entities:  

Keywords:  bile; biomarker; cholangiocarcinoma; serum

Mesh：

Substances：

Year:  2016        PMID： 27232281     DOI： 10.2217/bmm-2015-0062

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  8 in total

1.  Detection of early-stage extrahepatic cholangiocarcinoma in patients with biliary strictures by soluble B7-H4 in the bile.

Authors:  Wenbo Ke; Li Zeng; Yunbi Hu; Sisi Chen; Min Tian; Qinggang Hu
Journal:  Am J Cancer Res       Date:  2018-04-01       Impact factor: 6.166

2.  Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma.

Authors:  Elisa Herraez; Marta R Romero; Rocio I R Macias; Maria J Monte; Jose J G Marin
Journal:  Hepatobiliary Surg Nutr       Date:  2020-04       Impact factor: 7.293

3.  Epidemiology and Risk Factors of Cholangiocarcinoma.

Authors:  Martha M Kirstein; Arndt Vogel
Journal:  Visc Med       Date:  2016-12-01

4.  Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models.

Authors:  Malinee Thanee; Sureerat Padthaisong; Manida Suksawat; Hasaya Dokduang; Jutarop Phetcharaburanin; Poramate Klanrit; Attapol Titapun; Nisana Namwat; Arporn Wangwiwatsin; Prakasit Sa-Ngiamwibool; Narong Khuntikeo; Hideyuki Saya; Watcharin Loilome
Journal:  Cancer Metab       Date:  2021-03-16

5.  Serum levels of S100A6 are unaltered in patients with resectable cholangiocarcinoma.

Authors:  Sven H Loosen; Fabian Benz; Jennifer Niedeggen; Maximilian Schmeding; Florian Schüller; Alexander Koch; Mihael Vucur; Frank Tacke; Christian Trautwein; Christoph Roderburg; Ulf P Neumann; Tom Luedde
Journal:  Clin Transl Med       Date:  2016-09-27

6.  Imbalanced expression pattern of steroid receptor coactivator-1 and -3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray.

Authors:  Shan Li; Huiyan Zhang; Yanlan Yu; Mengying Liu; Deyu Guo; Xuqing Zhang; Jiqiang Zhang
Journal:  Oncol Lett       Date:  2018-09-17       Impact factor: 2.967

7.  Risk Factors of Clonorchis sinensis Human Infections in Endemic Areas, Haman-Gun, Republic of Korea: A Case-Control Study.

Authors:  Sang-Eun Lee; Hee-Eun Shin; Myoung-Ro Lee; Yang-Hee Kim; Shin-Hyeong Cho; Jung-Won Ju
Journal:  Korean J Parasitol       Date:  2020-12-29       Impact factor: 1.341

8.  Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer.

Authors:  Sven H Loosen; Annemarie Breuer; Frank Tacke; Jakob N Kather; Joao Gorgulho; Patrick H Alizai; Jan Bednarsch; Anjali A Roeth; Georg Lurje; Sophia M Schmitz; Jonathan F Brozat; Pia Paffenholz; Mihael Vucur; Thomas Ritz; Alexander Koch; Christian Trautwein; Tom F Ulmer; Christoph Roderburg; Thomas Longerich; Ulf P Neumann; Tom Luedde
Journal:  JHEP Rep       Date:  2020-01-31
  8 in total

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