| Literature DB >> 27230778 |
Prodip K Roy1, Runa Ashimine2, Haruna Miyazato3, Junsei Taira3, Katsuhiro Ueda4.
Abstract
Three cadinane-type sesquiterpenoids, endoperoxide (1) and hydroperoxides (2, 3) together with three known sesquiterpenoids (4-6) were isolated from an Okinawan soft coral, Sinularia species. Structures of these isolates were elucidated by spectroscopic analyses (NMR, IR and MS) and molecular modeling. In addition, the isolates 1-3 as new compounds were examined for biological activities, resulting that they have antibacterial activity and weak cytotoxicity against HCT116 cells as well as anti-inflammatory effect on LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.Entities:
Keywords: Anti-inflammatory; Cadinane; Cytotoxicity; HCT 116 cells; Sesquiterpenoid; Sinularia
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Year: 2016 PMID： 27230778 DOI： 10.1007/s12272-016-0759-z
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946