| Literature DB >> 27230393 |
Haidi Yang1,2, Hao Xiong1,2, Yongkang Ou1,2, Yaodong Xu1,2, Jiaqi Pang1,2, Lan Lai1,2, Yiqing Zheng3,4.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is one form of non-invasive brain stimulation and increasingly shows neuroprotection in multiple neurological disorders. However, the potential of rTMS for protective action on auditory function following acoustic trauma has not been investigated. Here, we examined effect of TMS on hearing conservation, neurons survival and brain-derived neurotrophin factor (BDNF) expression in the cochlea and auditory cortex following acoustic trauma in rats. Wistar rats were exposed to intense pure tone noise (10 kHz, 120 dB SPL for 2 h) followed by rTMS treatment or sham treatment (handling control) daily for 14 days. Auditory brainstem response revealed there was no significant difference in hearing threshold shifts between rTMS- and sham-treated rats, although rTMS-treated rats showed less neuron loss in the auditory cortex in comparison with sham rats. Additionally, acoustic trauma increased BDNF expression in the cochlea and auditory cortex, and this elevation could be attenuated by rTMS treatment. Our results suggest present regiment of rTMS does not protect hearing against acoustic trauma, but maybe have implications for tinnitus treatment.Entities:
Keywords: Acoustic trauma; Auditory cortex; Brain-derived neurotrophic factor; Repetitive transcranial magnetic stimulation; Tinnitus
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Year: 2016 PMID： 27230393 DOI： 10.1007/s10072-016-2603-0
Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307