Literature DB >> 2722996

Alpha 1-acid glycoprotein high-performance liquid chromatography column (EnantioPAC) as a screening tool for protein binding.

R C Jewell1, K L Brouwer, P J McNamara.   

Abstract

An attempt was made to correlate retention behavior on a high-performance liquid chromatographic (HPLC) system employing an immobilized alpha 1-acid glycoprotein (AAG) column with AAG binding behavior for various compounds. Protein binding was assessed by propranolol displacement studies in an equilibrium dialysis system using isolated AAG. HPLC retention behavior poorly correlated with propranolol displacement from AAG. This system is not suitable for use as a screening tool for AAG affinity.

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Year:  1989        PMID： 2722996     DOI： 10.1016/s0378-4347(00)83035-2

Source DB:  PubMed          Journal:  J Chromatogr


  5 in total

1.  Characterization of solution-phase drug-protein interactions by ultrafast affinity extraction.

Authors:  Sandya R Beeram; Xiwei Zheng; Kyungah Suh; David S Hage
Journal:  Methods       Date:  2018-03-03       Impact factor: 3.608

2.  Entrapment of alpha1-acid glycoprotein in high-performance affinity columns for drug-protein binding studies.

Authors:  Cong Bi; Abby Jackson; John Vargas-Badilla; Rong Li; Giana Rada; Jeanethe Anguizola; Erika Pfaunmiller; David S Hage
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2015-11-27       Impact factor: 3.205

Review 3.  Characterization of drug interactions with serum proteins by using high-performance affinity chromatography.

Authors:  David S Hage; Jeanethe Anguizola; Omar Barnaby; Abby Jackson; Michelle J Yoo; Efthimia Papastavros; Erika Pfaunmiller; Matt Sobansky; Zenghan Tong
Journal:  Curr Drug Metab       Date:  2011-05       Impact factor: 3.731

Review 4.  Characterization of drug-protein interactions in blood using high-performance affinity chromatography.

Authors:  David S Hage; Abby Jackson; Matthew R Sobansky; John E Schiel; Michelle J Yoo; K S Joseph
Journal:  J Sep Sci       Date:  2009-03       Impact factor: 3.645

5.  CHROMATOGRAPHIC ANALYSIS OF DRUG INTERACTIONS IN THE SERUM PROTEOME.

Authors:  David S Hage; Jeanethe A Anguizola; Abby J Jackson; Ryan Matsuda; Efthimia Papastavros; Erika Pfaunmiller; Zenghan Tong; John Vargas-Badilla; Michelle J Yoo; Xiwei Zheng
Journal:  Anal Methods       Date:  2011-07-01       Impact factor: 2.896
  5 in total

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