| Literature DB >> 27229877 |
Eri Nakayama1, Akira Kotaki1, Shigeru Tajima1, Miki Kawada2, Kuniharu Miura3, Aki Gemma4, Takuya Adachi4, Tsuyoshi Sekizuka5, Kengo Kato5, Akifumi Yamashita5, Meng Ling Moi1, Makiko Ikeda1, Kazumi Yagasaki1, Kenichi Shibasaki1, Masayuki Saijo1, Makoto Kuroda5, Tomohiko Takasaki6.
Abstract
In late August 2014, dengue cases were reported in Japan, and a total of 162 cases were confirmed. In the present study, the envelope (E) gene sequences of 12 specimens from the dengue patients were determined. A dengue virus serotype 1 (DENV1) strain (D1/Hu/Shizuoka/NIID181/2014), which was clearly different from the first reported strain (D1/Hu/Saitama/NIID100/2014), was identified, although the other 11 specimens showed the same nucleotide sequences as D1/Hu/Saitama/NIID100/2014. The E gene sequences of two different strains were compared with those of nine DENV1 strains of imported cases in Japan in 2014. Phylogenetic analysis based on the E gene sequences showed that the D1/Hu/Saitama/NIID100/2014 strain was closely related to a strain isolated from an imported case from Singapore. Although no strain closely related to D1/Hu/Shizuoka/NIID181/2014 was found in these imported strains, the strain was closely related to isolates in Thailand and Taiwan in 2009. These data indicate that the dengue cases in Japan were caused by two different dengue virus strains that entered Japan through different means.Entities:
Keywords: Aedes albopictus; Dengue; Dengue virus serotype 1; Envelope protein; Japan
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Year: 2016 PMID： 27229877 DOI： 10.1007/s11262-016-1356-4
Source DB: PubMed Journal: Virus Genes ISSN： 0920-8569 Impact factor: 2.332