Literature DB >> 27229638

Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays?

Timothy E Sweeney1, Hector R Wong2.   

Abstract

Sepsis mortality rates have decreased in recent years but remain unacceptably high. Risk stratification and prognostication is of particular importance because high-risk patients may benefit from earlier clinical interventions, whereas low-risk patients may benefit from not undergoing unnecessary procedures. Prognostication is currently done mostly via clinical criteria and blood lactate levels. This article summarizes the literature on the complexity of changes at the molecular level for the casual reader.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Biomarker; Gene expression; Microarray; Prognostics; Sepsis

Mesh：

Substances：

Year:  2016        PMID： 27229638      PMCID： PMC4884300          DOI： 10.1016/j.ccm.2016.01.003

Source DB:  PubMed          Journal:  Clin Chest Med        ISSN： 0272-5231            Impact factor:   2.878


  41 in total

1.  Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions.

Authors:  Grant P Parnell; Benjamin M Tang; Marek Nalos; Nicola J Armstrong; Stephen J Huang; David R Booth; Anthony S McLean
Journal:  Shock       Date:  2013-09       Impact factor: 3.454

2.  Prediction of multiple infections after severe burn trauma: a prospective cohort study.

Authors:  Shuangchun Yan; Amy Tsurumi; Yok-Ai Que; Colleen M Ryan; Arunava Bandyopadhaya; Alexander A Morgan; Patrick J Flaherty; Ronald G Tompkins; Laurence G Rahme
Journal:  Ann Surg       Date:  2015-04       Impact factor: 12.969

Review 3.  Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.

Authors:  Lori F Gentile; Alex G Cuenca; Philip A Efron; Darwin Ang; Azra Bihorac; Bruce A McKinley; Lyle L Moldawer; Frederick A Moore
Journal:  J Trauma Acute Care Surg       Date:  2012-06       Impact factor: 3.313

4.  Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.

Authors:  Erin L Vanzant; Cecilia M Lopez; Tezcan Ozrazgat-Baslanti; Ricardo Ungaro; Ruth Davis; Alex G Cuenca; Lori F Gentile; Dina C Nacionales; Angela L Cuenca; Azra Bihorac; Christiaan Leeuwenburgh; Jennifer Lanz; Henry V Baker; Bruce McKinley; Lyle L Moldawer; Frederick A Moore; Philip A Efron
Journal:  J Trauma Acute Care Surg       Date:  2014-01       Impact factor: 3.313

5.  Genomic responses in mouse models poorly mimic human inflammatory diseases.

Authors:  Junhee Seok; H Shaw Warren; Alex G Cuenca; Michael N Mindrinos; Henry V Baker; Weihong Xu; Daniel R Richards; Grace P McDonald-Smith; Hong Gao; Laura Hennessy; Celeste C Finnerty; Cecilia M López; Shari Honari; Ernest E Moore; Joseph P Minei; Joseph Cuschieri; Paul E Bankey; Jeffrey L Johnson; Jason Sperry; Avery B Nathens; Timothy R Billiar; Michael A West; Marc G Jeschke; Matthew B Klein; Richard L Gamelli; Nicole S Gibran; Bernard H Brownstein; Carol Miller-Graziano; Steve E Calvano; Philip H Mason; J Perren Cobb; Laurence G Rahme; Stephen F Lowry; Ronald V Maier; Lyle L Moldawer; David N Herndon; Ronald W Davis; Wenzhong Xiao; Ronald G Tompkins
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-11       Impact factor: 11.205

6.  Aberrant cell cycle and apoptotic changes characterise severe influenza A infection--a meta-analysis of genomic signatures in circulating leukocytes.

Authors:  Grant Parnell; Anthony McLean; David Booth; Stephen Huang; Marek Nalos; Benjamin Tang
Journal:  PLoS One       Date:  2011-03-08       Impact factor: 3.240

7.  Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.

Authors:  Rajit K Basu; Stephen W Standage; Natalie Z Cvijanovich; Geoffrey L Allen; Neal J Thomas; Robert J Freishtat; Nick Anas; Keith Meyer; Paul A Checchia; Richard Lin; Thomas P Shanley; Michael T Bigham; Derek S Wheeler; Prasad Devarajan; Stuart L Goldstein; Hector R Wong
Journal:  Crit Care       Date:  2011-11-18       Impact factor: 9.097

8.  Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram.

Authors:  Jonathan E McDunn; Kareem D Husain; Ashoka D Polpitiya; Anton Burykin; Jianhua Ruan; Qing Li; William Schierding; Nan Lin; David Dixon; Weixiong Zhang; Craig M Coopersmith; W Michael Dunne; Marco Colonna; Bijoy K Ghosh; J Perren Cobb
Journal:  PLoS One       Date:  2008-02-13       Impact factor: 3.240

9.  Early and dynamic changes in gene expression in septic shock patients: a genome-wide approach.

Authors:  Marie-Angélique Cazalis; Alain Lepape; Fabienne Venet; Florence Frager; Bruno Mougin; Hélène Vallin; Malick Paye; Alexandre Pachot; Guillaume Monneret
Journal:  Intensive Care Med Exp       Date:  2014-08-20

10.  The temporal version of the pediatric sepsis biomarker risk model.

Authors:  Hector R Wong; Scott L Weiss; John S Giuliano; Mark S Wainwright; Natalie Z Cvijanovich; Neal J Thomas; Geoffrey L Allen; Nick Anas; Michael T Bigham; Mark Hall; Robert J Freishtat; Anita Sen; Keith Meyer; Paul A Checchia; Thomas P Shanley; Jeffrey Nowak; Michael Quasney; Arun Chopra; Julie C Fitzgerald; Rainer Gedeit; Sharon Banschbach; Eileen Beckman; Kelli Harmon; Patrick Lahni; Christopher J Lindsell
Journal:  PLoS One       Date:  2014-03-13       Impact factor: 3.240
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  20 in total

Review 1.  Diagnosing and Managing Sepsis by Probing the Host Response to Infection: Advances, Opportunities, and Challenges.

Authors:  Ian L Gunsolus; Timothy E Sweeney; Oliver Liesenfeld; Nathan A Ledeboer
Journal:  J Clin Microbiol       Date:  2019-06-25       Impact factor: 5.948

2.  Host-Pathogen Interface: Progress in Understanding the Pathogenesis of Infection Due to Multidrug-Resistant Bacteria in the Intensive Care Unit.

Authors:  Danielle Ahn; Alice Prince
Journal:  J Infect Dis       Date:  2017-02-15       Impact factor: 5.226

3.  Sepsis Subclasses: Be Careful of What You Wish for.

Authors:  Lauren Jacobs; Hector R Wong
Journal:  Pediatr Crit Care Med       Date:  2017-06       Impact factor: 3.624

4.  Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis From Systemic Inflammatory Response Syndrome on Intensive Care Unit Admission.

Authors:  Sonia Y Velásquez; Anna Coulibaly; Carsten Sticht; Jutta Schulte; Bianka Hahn; Timo Sturm; Roman Schefzik; Manfred Thiel; Holger A Lindner
Journal:  Front Immunol       Date:  2022-06-30       Impact factor: 8.786

Review 5.  The immunopathology of sepsis and potential therapeutic targets.

Authors:  Tom van der Poll; Frank L van de Veerdonk; Brendon P Scicluna; Mihai G Netea
Journal:  Nat Rev Immunol       Date:  2017-04-24       Impact factor: 53.106

6.  A community approach to mortality prediction in sepsis via gene expression analysis.

Authors:  Timothy E Sweeney; Thanneer M Perumal; Ricardo Henao; Marshall Nichols; Judith A Howrylak; Augustine M Choi; Jesús F Bermejo-Martin; Raquel Almansa; Eduardo Tamayo; Emma E Davenport; Katie L Burnham; Charles J Hinds; Julian C Knight; Christopher W Woods; Stephen F Kingsmore; Geoffrey S Ginsburg; Hector R Wong; Grant P Parnell; Benjamin Tang; Lyle L Moldawer; Frederick E Moore; Larsson Omberg; Purvesh Khatri; Ephraim L Tsalik; Lara M Mangravite; Raymond J Langley
Journal:  Nat Commun       Date:  2018-02-15       Impact factor: 14.919

7.  Prospective Validation of a Transcriptomic Metric in Severe Trauma.

Authors:  Steven L Raymond; Russell B Hawkins; Zhongkai Wang; Juan C Mira; Julie A Stortz; Feifei Han; Jennifer D Lanz; Laura V Hennessy; Babette A Brumback; Henry V Baker; Philip A Efron; Scott C Brakenridge; Wenzhong Xiao; Ronald G Tompkins; Joseph Cuschieri; Frederick A Moore; Ronald V Maier; Lyle L Moldawer
Journal:  Ann Surg       Date:  2020-05       Impact factor: 13.787

8.  Tumor necrosis factor-α -308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis.

Authors:  Hao Wang; Shujin Guo; Chun Wan; Ting Yang; Ni Zeng; Yanqiu Wu; Lei Chen; Yongchun Shen; Fuqiang Wen
Journal:  Oncotarget       Date:  2017-09-13

9.  Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress Syndrome.

Authors:  Timothy E Sweeney; Neal J Thomas; Judie A Howrylak; Hector R Wong; Angela J Rogers; Purvesh Khatri
Journal:  Crit Care Med       Date:  2018-02       Impact factor: 7.598

Review 10.  Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics.

Authors:  Scott M Gordon; Lakshmi Srinivasan; Mary Catherine Harris
Journal:  Front Pediatr       Date:  2017-06-16       Impact factor: 3.418
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