Literature DB >> 27229619

Autoinflammation and HLA-B27: Beyond Antigen Presentation.

Cailin H Sibley1.   

Abstract

HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.

Entities:  

Keywords:  Autoinflammation; HLA-B27; IL-1; innate; spondyloarthritis

Mesh：

Substances：

Year:  2016        PMID： 27229619      PMCID： PMC4990066          DOI： 10.1080/09273948.2016.1175641

Source DB:  PubMed          Journal:  Ocul Immunol Inflamm        ISSN： 0927-3948            Impact factor:   3.070


  99 in total

1.  Impact of IL-1 signalling on experimental uveitis and arthritis.

Authors:  Stephen R Planck; April Woods; Jenna S Clowers; Martin J Nicklin; James T Rosenbaum; Holly L Rosenzweig
Journal:  Ann Rheum Dis       Date:  2012-01-20       Impact factor: 19.103

2.  No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis.

Authors:  Barbara Neerinckx; Shea Carter; Rik J Lories
Journal:  Ann Rheum Dis       Date:  2013-10-08       Impact factor: 19.103

3.  Association between KIR polymorphisms and ankylosing spondylitis in populations: a meta-analysis.

Authors:  Dazhi Fan; Si Liu; Ting Yang; Shanshan Wu; Sheng Wang; Guixing Li; Zhen Zeng; Zhenhua Duan; Guo Xia; Dongqing Ye; Yanfeng Zou; Shengqian Xu; Jianhua Xu; Li Zhang; Zongwen Shuai; Faming Pan
Journal:  Mod Rheumatol       Date:  2014-03-27       Impact factor: 3.023

4.  HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease.

Authors:  Matthew J Turner; Monica L Delay; Shuzhen Bai; Erin Klenk; Robert A Colbert
Journal:  Arthritis Rheum       Date:  2007-01

5.  Ankylosing spondylitis: klebsiella and HL-A B27.

Authors:  R Ebringer; D Cooke; D R Cawdell; P Cowling; A Ebringer
Journal:  Rheumatol Rehabil       Date:  1977-08

6.  Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

Authors:  Yu-Lian Jiao; Bing-Chang Zhang; Li You; Jian-Feng Li; Jie Zhang; Chun-Yan Ma; Bin Cui; Lai-Cheng Wang; Zi-Jiang Chen; Yue-Ran Zhao
Journal:  J Clin Immunol       Date:  2010-07-21       Impact factor: 8.317

7.  Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium.

Authors: 
Journal:  Cell       Date:  1997-08-22       Impact factor: 41.582

Review 8.  Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory?

Authors:  Carmen Ambarus; Nataliya Yeremenko; Paul P Tak; Dominique Baeten
Journal:  Curr Opin Rheumatol       Date:  2012-07       Impact factor: 5.006

9.  IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity.

Authors:  Tamara Kopp; Petra Lenz; Concha Bello-Fernandez; Robert A Kastelein; Thomas S Kupper; Georg Stingl
Journal:  J Immunol       Date:  2003-06-01       Impact factor: 5.422

10.  Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Authors:  John Bowes; Ashley Budu-Aggrey; Ulrike Huffmeier; Steffen Uebe; Kathryn Steel; Harry L Hebert; Chris Wallace; Jonathan Massey; Ian N Bruce; James Bluett; Marie Feletar; Ann W Morgan; Helena Marzo-Ortega; Gary Donohoe; Derek W Morris; Philip Helliwell; Anthony W Ryan; David Kane; Richard B Warren; Eleanor Korendowych; Gerd-Marie Alenius; Emiliano Giardina; Jonathan Packham; Ross McManus; Oliver FitzGerald; Neil McHugh; Matthew A Brown; Pauline Ho; Frank Behrens; Harald Burkhardt; Andre Reis; Anne Barton
Journal:  Nat Commun       Date:  2015-02-05       Impact factor: 14.919
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  3 in total

Review 1.  The Conundrum of Psoriatic Arthritis: a Pathogenetic and Clinical Pattern at the Midpoint of Autoinflammation and Autoimmunity.

Authors:  Rossana Scrivo; Salvatore D'Angelo; Antonio Carriero; Chiara Castellani; Fabio Massimo Perrotta; Fabrizio Conti; Matteo Vecellio; Carlo Selmi; Ennio Lubrano
Journal:  Clin Rev Allergy Immunol       Date:  2022-01-18       Impact factor: 8.667

Review 2.  "Photobiomics": Can Light, Including Photobiomodulation, Alter the Microbiome?

Authors:  Ann Liebert; Brian Bicknell; Daniel M Johnstone; Luke C Gordon; Hosen Kiat; Michael R Hamblin
Journal:  Photobiomodul Photomed Laser Surg       Date:  2019-10-09

Review 3.  Nutrition in Spondyloarthritis and Related Immune-Mediated Disorders.

Authors:  Stefan Lucian Popa; Dinu Iuliu Dumitrascu; Vlad Dumitru Brata; Traian Adrian Duse; Maria Delia Florea; Abdulrahman Ismaiel; Laura Mirela Muntean; Simona Grad
Journal:  Nutrients       Date:  2022-03-17       Impact factor: 5.717
  3 in total

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