BACKGROUND:Balneotherapy is one of the most commonly used non-pharmacological approaches for osteoarthritis (OA). Recent data indicate that some biomarkers could be useful to predict OA progression and to assess therapeutic response. OBJECTIVES: To evaluate the effects of mud-bath therapy on serum biomarkers in patients with knee OA. METHODS: The study group comprised 103 patients with primary symptomatic bilateral knee OA who were randomly assigned to receive a cycle of mud-bath therapy over a period of 2 weeks or to continue their standard therapy alone. Clinical and biochemical parameters were assessed at baseline and after 2 weeks. Clinical assessments included global pain score on a visual analogue scale (VAS) and the Western Ontario and McMaster Universities Index (WOMAC) subscores for knee OA. Cartilage oligomeric matrix protein (COMP), C-terminal cross-linked telopeptide type II collagen (CTX-II), myeloperoxidase (MPO) and high sensitivity C-reactive protein (hsCRP) serum levels were assessed by ELISA. RESULTS: At the end of mud-bath therapy we observed a statistically significant improvement in VAS and WOMAC subscores. Serum levels of COMP, MPO and hsCRP did not show any significant modification in either group, while a significant increase (P < 0.001) in CTX-II serum levels was observed in the mud-bath group after the treatment. CONCLUSIONS: A cycle of mud-bath therapy added to the usual treatment had a beneficial effect on pain and function in patients with knee OA. The evaluation of serum biomarkers showed a significant increase of CTX-II only, perhaps due to an increase of cartilage turnover induced by thermal stress.
RCT Entities:
BACKGROUND: Balneotherapy is one of the most commonly used non-pharmacological approaches for osteoarthritis (OA). Recent data indicate that some biomarkers could be useful to predict OA progression and to assess therapeutic response. OBJECTIVES: To evaluate the effects of mud-bath therapy on serum biomarkers in patients with knee OA. METHODS: The study group comprised 103 patients with primary symptomatic bilateral knee OA who were randomly assigned to receive a cycle of mud-bath therapy over a period of 2 weeks or to continue their standard therapy alone. Clinical and biochemical parameters were assessed at baseline and after 2 weeks. Clinical assessments included global pain score on a visual analogue scale (VAS) and the Western Ontario and McMaster Universities Index (WOMAC) subscores for knee OA. Cartilage oligomeric matrix protein (COMP), C-terminal cross-linked telopeptide type II collagen (CTX-II), myeloperoxidase (MPO) and high sensitivity C-reactive protein (hsCRP) serum levels were assessed by ELISA. RESULTS: At the end of mud-bath therapy we observed a statistically significant improvement in VAS and WOMAC subscores. Serum levels of COMP, MPO and hsCRP did not show any significant modification in either group, while a significant increase (P < 0.001) in CTX-II serum levels was observed in the mud-bath group after the treatment. CONCLUSIONS: A cycle of mud-bath therapy added to the usual treatment had a beneficial effect on pain and function in patients with knee OA. The evaluation of serum biomarkers showed a significant increase of CTX-II only, perhaps due to an increase of cartilage turnover induced by thermal stress.
Authors: Tamás Gáti; Ildikó Katalin Tefner; Lajos Kovács; Katalin Hodosi; Tamás Bender Journal: Int J Biometeorol Date: 2018-01-10 Impact factor: 3.787
Authors: Paulo Fávio Macedo Gouvêa; Zélia Maria Nogueira Britschka; Cristina de Oliveira Massoco Salles Gomes; Nicolle Gilda Teixeira de Queiroz; Pablo Antonio Vásquez Salvador; Paulo Sergio Cardoso Silva Journal: Int J Environ Res Public Health Date: 2021-02-09 Impact factor: 3.390
Authors: V Tékus; É Borbély; T Kiss; A Perkecz; Á Kemény; J Horváth; A Kvarda; E Pintér Journal: Evid Based Complement Alternat Med Date: 2018-08-27 Impact factor: 2.629