| Literature DB >> 27228391 |
Alexander H Mo1, Preston B Landon2, Karla Santacruz Gomez3, Heemin Kang4, Joon Lee1, Chen Zhang5, Woraphong Janetanakit5, Vrinda Sant6, Tianyu Lu6, David A Colburn6, Siddhartha Akkiraju5, Samuel Dossou5, Yue Cao6, Kuo-Fen Lee7, Shyni Varghese8, Gennadi Glinsky9, Ratnesh Lal10.
Abstract
Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.Entities:
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Year: 2016 PMID： 27228391 PMCID： PMC6295298 DOI： 10.1039/c6nr02445a
Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790