| Literature DB >> 27227573 |
Haijun Tian1,2, Juanjuan Du, Jing Wen, Yang Liu, Scott R Montgomery, Trevor P Scott, Bayan Aghdasi, Chengjie Xiong, Akinobu Suzuki, Tetsuo Hayashi, Monchai Ruangchainikom, Kevin Phan, Gil Weintraub, Alobaidaan Raed, Samuel S Murray3, Michael D Daubs4, Xianjin Yang5, Xu-Bo Yuan5, Jeffrey C Wang6, Yunfeng Lu.
Abstract
Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.Entities:
Keywords: bone regeneration; controlled release; degradable polymer; inflammation; protein nanocapsule
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Year: 2016 PMID： 27227573 DOI： 10.1021/acsnano.5b07950
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881