Maria Teruel1, Marta E Alarcón-Riquelme. 1. aGENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Parque Tecnológico de la Salud, Granada, Spain bUnit of Chronic Inflammatory Diseases, Institute for Environmental Medicine IMM, Karolinska Institutet, Solna, Sweden.
Abstract
PURPOSE OF REVIEW: To describe the recent studies on the genetics of systemic lupus erythematosus (SLE) and Sjögren's syndrome. RECENT FINDINGS: We overview the most recent findings on the genetic susceptibility of the diseases and provide information on their genetic similarities and differences. SUMMARY: SLE and Sjögren's syndrome are two closely related systemic autoimmune diseases that share multiple clinical and molecular aspects, including a significant number of susceptibility genes. Several genome-wide association studies were recently published in different populations that provide a better picture of their molecular mechanisms. It is becoming clear that their genetic architecture is quite well established, but more information is required on expression quantitative trait loci, epigenetic genome-wide analyses, gene × gene interactions and the role of rare variants.
PURPOSE OF REVIEW: To describe the recent studies on the genetics of systemic lupus erythematosus (SLE) and Sjögren's syndrome. RECENT FINDINGS: We overview the most recent findings on the genetic susceptibility of the diseases and provide information on their genetic similarities and differences. SUMMARY:SLE and Sjögren's syndrome are two closely related systemic autoimmune diseases that share multiple clinical and molecular aspects, including a significant number of susceptibility genes. Several genome-wide association studies were recently published in different populations that provide a better picture of their molecular mechanisms. It is becoming clear that their genetic architecture is quite well established, but more information is required on expression quantitative trait loci, epigenetic genome-wide analyses, gene × gene interactions and the role of rare variants.
Authors: Rashi Gupta; Emma Vanlieshout; Kieran Manion; Dennisse Bonilla; Michael Kim; Carolina Muñoz-Grajales; Carol Nassar; Sindhu R Johnson; Linda T Hiraki; Zareen Ahmad; Zahi Touma; Arthur Bookman; Joan E Wither Journal: Front Immunol Date: 2022-06-30 Impact factor: 8.786
Authors: Somnath Bandyopadhyay; Sean E Connolly; Omar Jabado; June Ye; Sheila Kelly; Michael A Maldonado; Rene Westhovens; Peter Nash; Joan T Merrill; Robert M Townsend Journal: Lupus Sci Med Date: 2017-07-28