Literature DB >> 27226934

Poring over two-pore channel pore mutants.

Christopher J Penny1, Sandip Patel1.   

Abstract

Two-pore channels are members of the voltage-gated ion channel superfamily. They localise to the endolysosomal system and are likely targets for the Ca2+ mobilising messenger NAADP. In this brief review, we relate mutagenesis of the TPC pore to a recently published homology model and discuss how pore mutants are informing us of TPC function. Molecular physiology of these ubiquitous proteins is thus emerging.

Entities:  

Keywords:  NAADP; TPC1; TPC2; homology modelling; site-directed mutagenesis; structure-function; voltage-gated ion channel

Year:  2015        PMID： 27226934      PMCID： PMC4876920          DOI： 10.1166/msr.2015.1044

Source DB:  PubMed          Journal:  Messenger (Los Angel)


  53 in total

1.  Calcium signaling: NAADP ascends as a new messenger.

Authors:  Hon Cheung Lee
Journal:  Curr Biol       Date:  2003-03-04       Impact factor: 10.834

2.  Degeneration of an intracellular ion channel in the primate lineage by relaxation of selective constraints.

Authors:  Xinjiang Cai; Sandip Patel
Journal:  Mol Biol Evol       Date:  2010-05-12       Impact factor: 16.240

3.  The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.

Authors:  Yaping Lin-Moshier; Michael V Keebler; Robert Hooper; Michael J Boulware; Xiaolong Liu; Dev Churamani; Mary E Abood; Timothy F Walseth; Eugen Brailoiu; Sandip Patel; Jonathan S Marchant
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-25       Impact factor: 11.205

4.  Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.

Authors:  David Shaya; Felix Findeisen; Fayal Abderemane-Ali; Cristina Arrigoni; Stephanie Wong; Shailika Reddy Nurva; Gildas Loussouarn; Daniel L Minor
Journal:  J Mol Biol       Date:  2013-10-10       Impact factor: 5.469

5.  Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

Authors:  Michael Schieder; Katrin Rötzer; Andrea Brüggemann; Martin Biel; Christian A Wahl-Schott
Journal:  J Biol Chem       Date:  2010-05-21       Impact factor: 5.157

6.  An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.

Authors:  Eugen Brailoiu; Taufiq Rahman; Dev Churamani; David L Prole; G Cristina Brailoiu; Robert Hooper; Colin W Taylor; Sandip Patel
Journal:  J Biol Chem       Date:  2010-09-29       Impact factor: 5.157

7.  The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.

Authors:  Dev Churamani; Robert Hooper; Taufiq Rahman; Eugen Brailoiu; Sandip Patel
Journal:  Biochem J       Date:  2013-07-01       Impact factor: 3.857

8.  Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases.

Authors:  Archana Jha; Malini Ahuja; Sandip Patel; Eugen Brailoiu; Shmuel Muallem
Journal:  EMBO J       Date:  2014-02-05       Impact factor: 11.598

Review 9.  A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.

Authors:  Antony Galione
Journal:  Cell Calcium       Date:  2014-10-07       Impact factor: 6.817

10.  Questioning regulation of two-pore channels by NAADP.

Authors:  Jonathan S Marchant; Sandip Patel
Journal:  Messenger (Los Angel)       Date:  2013-06-01
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  4 in total

1.  Lysosomal Calcium in Neurodegeneration.

Authors:  Xinghua Feng; Junsheng Yang
Journal:  Messenger (Los Angel)       Date:  2016-06-01

Review 2.  Calcium Dyshomeostasis and Lysosomal Ca2+ Dysfunction in Amyotrophic Lateral Sclerosis.

Authors:  Valentina Tedeschi; Tiziana Petrozziello; Agnese Secondo
Journal:  Cells       Date:  2019-10-08       Impact factor: 6.600

3.  Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.

Authors:  Yu Yuan; Dawid Jaślan; Taufiq Rahman; Stephen R Bolsover; Vikas Arige; Larry E Wagner; Carla Abrahamian; Rachel Tang; Marco Keller; Jonas Hartmann; Anna S Rosato; Eva-Maria Weiden; Franz Bracher; David I Yule; Christian Grimm; Sandip Patel
Journal:  Nat Commun       Date:  2022-08-02       Impact factor: 17.694

Review 4.  Two-pore channels and disease.

Authors:  Sandip Patel; Bethan S Kilpatrick
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2018-05-07       Impact factor: 4.739
  4 in total

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