Literature DB >> 27226376

Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68.

Xing Jia1,2, Sheng Shen1, Ying Lv1,2, Ziwei Zhang1,2, Haitao Guo1, Hongyu Deng3,4.   

Abstract

Tegument proteins play critical roles in herpesvirus morphogenesis. ORF45 is a conserved tegument protein of gammaherpesviruses; however, its role in virion morphogenesis is largely unknown. In this work, we determined the ultrastructural localization of murine gammaherpesvirus 68 (MHV-68) ORF45 and found that this protein was incorporated into virions around the site of host-derived vesicles. Notably, the absence of ORF45 inhibited nucleocapsid egress and blocked cytoplasmic virion maturation, demonstrating that ORF45 is essential for MHV-68 virion morphogenesis.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27226376      PMCID： PMC4984643          DOI： 10.1128/JVI.03231-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Complete sequence and genomic analysis of murine gammaherpesvirus 68.

Authors:  H W Virgin; P Latreille; P Wamsley; K Hallsworth; K E Weck; A J Dal Canto; S H Speck
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

Authors:  Joseph Gillen; Wenwei Li; Qiming Liang; Denis Avey; Jianjun Wu; Fayi Wu; JinJong Myoung; Fanxiu Zhu
Journal:  J Virol       Date:  2015-02-18       Impact factor: 5.103

3.  Three-dimensional visualization of gammaherpesvirus life cycle in host cells by electron tomography.

Authors:  Li Peng; Sergey Ryazantsev; Ren Sun; Z Hong Zhou
Journal:  Structure       Date:  2010-01-13       Impact factor: 5.006

4.  A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation.

Authors:  Fan Xiu Zhu; Sonya M King; Eric J Smith; David E Levy; Yan Yuan
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

5.  The human cytomegalovirus (HCMV) tegument protein UL94 is essential for secondary envelopment of HCMV virions.

Authors:  Stacia L Phillips; Wade A Bresnahan
Journal:  J Virol       Date:  2011-12-14       Impact factor: 5.103

6.  Distinct domains in ORF52 tegument protein mediate essential functions in murine gammaherpesvirus 68 virion tegumentation and secondary envelopment.

Authors:  Lili Wang; Haitao Guo; Nichole Reyes; Shaoying Lee; Eric Bortz; Fengli Guo; Ren Sun; Liang Tong; Hongyu Deng
Journal:  J Virol       Date:  2011-11-16       Impact factor: 5.103

7.  Fluorescent tagging and cellular distribution of the Kaposi's sarcoma-associated herpesvirus ORF45 tegument protein.

Authors:  Shir Bergson; Inna Kalt; Inbal Itzhak; Kevin F Brulois; Jae U Jung; Ronit Sarid
Journal:  J Virol       Date:  2014-08-27       Impact factor: 5.103

8.  Identification of the nuclear export and adjacent nuclear localization signals for ORF45 of Kaposi's sarcoma-associated herpesvirus.

Authors:  Xiaojuan Li; Fanxiu Zhu
Journal:  J Virol       Date:  2008-12-30       Impact factor: 5.103

9.  Identification of proteins associated with murine gammaherpesvirus 68 virions.

Authors:  Eric Bortz; Julian P Whitelegge; Qingmei Jia; Z Hong Zhou; James P Stewart; Ting-Ting Wu; Ren Sun
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

10.  Mono-ubiquitylated ORF45 Mediates Association of KSHV Particles with Internal Lipid Rafts for Viral Assembly and Egress.

Authors:  Xin Wang; Nannan Zhu; Wenwei Li; Fanxiu Zhu; Yan Wang; Yan Yuan
Journal:  PLoS Pathog       Date:  2015-12-09       Impact factor: 6.823
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  8 in total

1.  Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus.

Authors:  Qiming Liang; Dahai Wei; Brian Chung; Kevin F Brulois; Changrun Guo; Shupeng Dong; Shou-Jiang Gao; Pinghui Feng; Chengyu Liang; Jae U Jung
Journal:  J Virol       Date:  2018-01-30       Impact factor: 5.103

2.  Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.

Authors:  H M Abdullah Al Masud; Takahiro Watanabe; Masahiro Yoshida; Yoshitaka Sato; Fumi Goshima; Hiroshi Kimura; Takayuki Murata
Journal:  J Virol       Date:  2017-11-14       Impact factor: 5.103

3.  KSHV-encoded ORF45 activates human NLRP1 inflammasome.

Authors:  Xing Yang; Jingfan Zhou; Chengrong Liu; Yafei Qu; Weili Wang; Maggie Z X Xiao; Fanxiu Zhu; Zhenshan Liu; Qiming Liang
Journal:  Nat Immunol       Date:  2022-05-26       Impact factor: 31.250

4.  Liquid-liquid phase separation mediates the formation of herpesvirus assembly compartments.

Authors:  Sheng Zhou; Zhifei Fu; Ziwei Zhang; Xing Jia; Guangjun Xu; Long Sun; Fei Sun; Pu Gao; Pingyong Xu; Hongyu Deng
Journal:  J Cell Biol       Date:  2022-10-17       Impact factor: 8.077

5.  The ORF45 Protein of Kaposi Sarcoma-Associated Herpesvirus Is an Inhibitor of p53 Signaling during Viral Reactivation.

Authors:  Dina Alzhanova; James O Meyo; Angelica Juarez; Dirk P Dittmer
Journal:  J Virol       Date:  2021-09-15       Impact factor: 5.103

Review 6.  The ORF45 Protein of Kaposi's Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle.

Authors:  Natalie Atyeo; Bernadett Papp
Journal:  Viruses       Date:  2022-09-11       Impact factor: 5.818

7.  Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Authors:  Nick D Van Skike; Nana K Minkah; Chad H Hogan; Gary Wu; Peter T Benziger; Darby G Oldenburg; Mehmet Kara; Deborah M Kim-Holzapfel; Douglas W White; Scott A Tibbetts; Jarrod B French; Laurie T Krug
Journal:  PLoS Pathog       Date:  2018-02-01       Impact factor: 6.823

8.  Disruption of the Interaction between ORF33 and the Conserved Carboxyl-Terminus of ORF45 Abolishes Progeny Virion Production of Kaposi Sarcoma-Associated Herpesvirus.

Authors:  Joseph Gillen; Fanxiu Zhu
Journal:  Viruses       Date:  2021-09-14       Impact factor: 5.048
  8 in total

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