| Literature DB >> 27226206 |
Atis Muehlenbachs1, Olimpia de la Rosa Vázquez2, Daniel G Bausch3, Ilana J Schafer3, Christopher D Paddock4, Jean Paul Nyakio5, Papys Lame5, Eric Bergeron3, Andrea M McCollum6, Cynthia S Goldsmith1, Brigid C Bollweg1, Miriam Alía Prieto2, Robert Shongo Lushima7, Benoit Kebela Ilunga7, Stuart T Nichol3, Wun-Ju Shieh1, Ute Ströher3, Pierre E Rollin3, Sherif R Zaki1.
Abstract
Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.Entities:
Keywords: Bundibugyo virus; Ebola virus disease; Sudan virus; malaria; pathology; placenta; pregnancy
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Year: 2016 PMID： 27226206 DOI： 10.1093/infdis/jiw206
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226