| Literature DB >> 27225852 |
Motoyuki Otsuka1,2, Takahiro Kishikawa1, Takeshi Yoshikawa1, Mari Yamagami1, Motoko Ohno1, Akemi Takata1, Chikako Shibata1, Rei Ishibashi1, Kazuhiko Koike1.
Abstract
The biological roles of microRNAs (miRNAs) have been extensively studied. miRNA122 represents more than half of the miRNAs expressed in the liver and has various physiological and pathological functions, which include enhancing hepatitis virus replication, regulating lipid metabolism and suppressing hepatocellular carcinoma. miRNAs, whether globally or individually, have been linked with hepatocarcinogenesis. Furthermore, some miRNAs have been shown to be involved in the pathogenesis of nonalcoholic steatohepatitis. Using nucleotide-based strategies, these miRNAs may be developed as potential therapeutic targets. Because changes in miRNA expression can be measured in sera, they may be used as non-invasive biomarkers if they correctly reflect the pathological state of the liver. In this review, we show the biological roles of representative miRNAs in liver disease and discuss the current issues that remain to be clarified for future clinical applications.Entities:
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Year: 2016 PMID： 27225852 DOI： 10.1038/jhg.2016.53
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172