| Literature DB >> 27225847 |
Hung-Pin Tu1, Chia-Min Chung2, Albert Min-Shan Ko3, Su-Shin Lee4, Han-Ming Lai5, Chien-Hung Lee6, Chung-Ming Huang7, Chiu-Shong Liu8, Ying-Chin Ko2,9.
Abstract
The aim of the present study was to evaluate the contribution of urate transporter genes and alcohol use to the risk of gout/tophi. Eight variants of ABCG2, SLC2A9, SLC22A12, SLC22A11 and SLC17A3 were genotyped in male individuals in a case-control study with 157 gout (33% tophi), 106 asymptomatic hyperuricaemia and 295 control subjects from Taiwan. The multilocus profiles of the genetic risk scores for urate gene variants were used to evaluate the risk of asymptomatic hyperuricaemia, gout and tophi. ABCG2 Q141K (T), SLC2A9 rs1014290 (A) and SLC22A12 rs475688 (C) under an additive model and alcohol use independently predicted the risk of gout (respective odds ratio for each factor=2.48, 2.03, 1.95 and 2.48). The additive composite Q141K, rs1014290 and rs475688 scores of high-risk alleles were associated with gout risk (P<0.0001). We observed the supramultiplicative interaction effect of genetic urate scores and alcohol use on gout and tophi risk (P for interaction=0.0452, 0.0033). The synergistic effect of genetic urate score 5-6 and alcohol use indicates that these combined factors correlate with gout and tophi occurrence.Entities:
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Year: 2016 PMID： 27225847 DOI： 10.1038/jhg.2016.57
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172