Mehmet Bulut1, Aylin Yaman2, Muhammet Kazim Erol1, Fatma Kurtuluş2, Devrim Toslak1, Deniz Turgut Coban1, Ebru Kaya Başar3. 1. Ophthalmology Department, Antalya Training and Research Hospital, Antalya, Turkey. 2. Neurology Department, Antalya Training and Research Hospital, Antalya, Turkey. 3. Department of Animal Science Biometry and Genetics Unit, Faculty of Agriculture, Akdeniz University, Akdeniz, Turkey.
Abstract
PURPOSE: To assess cognitive performance differences among primary open-angle glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy control (C) subjects. METHODS: A total of 60 participants (20 POAG, 20 NTG, and 20 C subjects) were included in this study. A detailed ophthalmologic examination was performed on all participants. A spectral domain-optical coherence tomography (SD-OCT) system was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses. To assess the cognitive performance of all participants, detailed neurological examinations, including the mini-mental state examination (MMSE), were performed by the same neurologist. RESULTS: There were no significant differences among the groups in terms of age (p =0.348) or gender (p =0.935). The mean RNFL thicknesses were significantly different among the groups (85.2 ± 14.7, 76.8 ± 10.3, and 91.4 ± 7.7 µm in the POAG, NTG, and C subjects, respectively; p <0.001). The mean GC-IPL thicknesses were 77.5 ± 9.7 µm in the POAG group, 73.4 ± 7.8 µm in the NTG group, and 78.8 ± 3.8 µm in the C group. Differences among the groups were not statistically significant (p =0.085). MMSE scores were 26.1 ± 1.4, 25.7 ± 2.3, and 28.8 ± 0.9 in the POAG, NTG, and C groups, respectively. There were significant differences among the three groups (p <0.001). Specifically, there were significant differences between the NTG and C groups (p <0.001), and between the POAG and C groups (p =0.001). There was no significant difference between the POAG and NTG groups (p =0.595). CONCLUSIONS: There appear to be similar risk factors in glaucoma and neurodegenerative disorders that cause deterioration in cognitive performance. Comparing the low MMSE scores of the POAG and NTG patients with the scores of healthy C participants supports our hypothesis. Consequently, it is recommended that a neurologist should also examine glaucoma patients.
PURPOSE: To assess cognitive performance differences among primary open-angle glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy control (C) subjects. METHODS: A total of 60 participants (20 POAG, 20 NTG, and 20 C subjects) were included in this study. A detailed ophthalmologic examination was performed on all participants. A spectral domain-optical coherence tomography (SD-OCT) system was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses. To assess the cognitive performance of all participants, detailed neurological examinations, including the mini-mental state examination (MMSE), were performed by the same neurologist. RESULTS: There were no significant differences among the groups in terms of age (p =0.348) or gender (p =0.935). The mean RNFL thicknesses were significantly different among the groups (85.2 ± 14.7, 76.8 ± 10.3, and 91.4 ± 7.7 µm in the POAG, NTG, and C subjects, respectively; p <0.001). The mean GC-IPL thicknesses were 77.5 ± 9.7 µm in the POAG group, 73.4 ± 7.8 µm in the NTG group, and 78.8 ± 3.8 µm in the C group. Differences among the groups were not statistically significant (p =0.085). MMSE scores were 26.1 ± 1.4, 25.7 ± 2.3, and 28.8 ± 0.9 in the POAG, NTG, and C groups, respectively. There were significant differences among the three groups (p <0.001). Specifically, there were significant differences between the NTG and C groups (p <0.001), and between the POAG and C groups (p =0.001). There was no significant difference between the POAG and NTG groups (p =0.595). CONCLUSIONS: There appear to be similar risk factors in glaucoma and neurodegenerative disorders that cause deterioration in cognitive performance. Comparing the low MMSE scores of the POAG and NTG patients with the scores of healthy C participants supports our hypothesis. Consequently, it is recommended that a neurologist should also examine glaucomapatients.
Authors: Teresa Zwierko; Wojciech Jedziniak; Piotr Lesiakowski; Marta Śliwiak; Marta Kirkiewicz; Wojciech Lubiński Journal: Int J Environ Res Public Health Date: 2019-11-07 Impact factor: 3.390
Authors: Teresa Zwierko; Wojciech Jedziniak; Beata Florkiewicz; Piotr Lesiakowski; Marta Śliwiak; Marta Kirkiewicz; Wojciech Lubiński Journal: Int J Environ Res Public Health Date: 2022-02-03 Impact factor: 3.390
Authors: Sean Mullany; Lewis Xiao; Ayub Qassim; Henry Marshall; Puya Gharahkhani; Stuart MacGregor; Mark M Hassall; Owen M Siggs; Emmanuelle Souzeau; Jamie E Craig Journal: Br J Ophthalmol Date: 2021-03-29 Impact factor: 5.908
Authors: K S Vidal; C K Suemoto; A B Moreno; B Duncan; M I Schmidt; M Maestri; S M Barreto; P A Lotufo; L Bertola; I M Bensenor; A R Brunoni Journal: Braz J Med Biol Res Date: 2020-10-30 Impact factor: 2.590
Authors: David E Anderson; John P Bader; Emily A Boes; Meghal Gagrani; Lynette M Smith; Jideofor K Ndulue; Sachin Kedar; Vikas Gulati; Deepta A Ghate; Matthew Rizzo Journal: BMC Ophthalmol Date: 2020-10-20 Impact factor: 2.209