BACKGROUND: Liposclerosing myxofibrous primary bone tumor is a rare benign bone lesion that was characterized by complex mixture of various histological elements. METHODS: We have studied the radiological, clinical and pathological features of nine patients with this disorder. Pain and limping were the main symptoms. RESULTS: Radiographic images typically showed a geographic lytic lesion with thick sclerotic margin, reflecting a pattern of slow growth. Histological sections revealed a polymorphic neoplasia characterized by predominant proliferation of stellate and fusiform cells aimed the myxoid matrix. CONCLUSIONS: These features suggest that the lesion may represent a variant of fibrous dysplasia with a high risk of malignant transformation.
BACKGROUND: Liposclerosing myxofibrous primary bone tumor is a rare benign bone lesion that was characterized by complex mixture of various histological elements. METHODS: We have studied the radiological, clinical and pathological features of nine patients with this disorder. Pain and limping were the main symptoms. RESULTS: Radiographic images typically showed a geographic lytic lesion with thick sclerotic margin, reflecting a pattern of slow growth. Histological sections revealed a polymorphic neoplasia characterized by predominant proliferation of stellate and fusiform cells aimed the myxoid matrix. CONCLUSIONS: These features suggest that the lesion may represent a variant of fibrous dysplasia with a high risk of malignant transformation.
Entities:
Keywords:
Bone tumors; Liposclerosing myxofibrous tumor; Series of cases
Authors: Alessandro Corsi; Fernando De Maio; Ernesto Ippolito; Natasha Cherman; Pamela Gehron Robey; Mara Riminucci; Paolo Bianco Journal: J Bone Miner Res Date: 2006-12 Impact factor: 6.741
Authors: Mark D Murphey; John F Carroll; Donald J Flemming; Thomas L Pope; Francis H Gannon; Mark J Kransdorf Journal: Radiographics Date: 2004 Sep-Oct Impact factor: 5.333