Literature DB >> 27222617

A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery after surgery (ERAS) total knee replacement.

Georgios I Drosos1, Athanasios Ververidis1, Christos Valkanis1, Grigorios Tripsianis2, Eftihios Stavroulakis3, Theodosia Vogiatzaki3, Konstantinos Kazakos1.   

Abstract

BACKGROUND: The aim of this study was to compare the topical to IV tranexamic acid (TXA) administration of the same dose, given at the same time in patients who underwent TKR using an enhanced recovery after surgery (ERAS) regime.
METHODS: Ninety patients were randomized in control group, and IV and topical application groups received 1 g TXA.
RESULTS: Blood loss and transfusion requirements in control group were statistically higher compared to both TXA groups (p < 0.05). Length of stay was the same in all groups.
CONCLUSIONS: TXA reduced significantly the blood loss and the need for transfusion in ERAS primary unilateral TKR.

Entities:  

Keywords:  Blood loss; Total knee replacement; Tourniquet; Tranexamic acid; Transfusion

Year:  2016        PMID： 27222617      PMCID： PMC4821446          DOI： 10.1016/j.jor.2016.03.007

Source DB:  PubMed          Journal:  J Orthop        ISSN： 0972-978X


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