Byung Kwan Park1, Ji Won Park1,2,3, Eon Chul Han1, Seung-Bum Ryoo1, Sae-Won Han2,3,4, Tae-You Kim2,3,4, Eui Kyu Chie5, Seung-Yong Jeong1,2,3, Kyu Joo Park1,3. 1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. 2. Cancer Research Institute, Seoul National University, Seoul, Korea. 3. Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea. 4. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. 5. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
BACKGROUND: The aim of this study was to evaluate systemic inflammatory markers as prognostic factors in patients with stage IIA colorectal cancer. METHODS: Among the patients who underwent curative resection for colorectal cancer at Seoul National University Hospital between 2002 and 2010, 1,035 who were classified as postoperative pathologic stage IIA (T3N0M0) were included. Systemic inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and serum fibrinogen level, were retrospectively reviewed. The patients were divided into two groups according to the cut-off values of the systemic inflammatory markers after receiver operating characteristic (ROC) curve analysis. Survival analysis was performed to identify factors associated with disease-free survival (DFS) and overall survival (OS). RESULTS: Age, American Society of Anesthesiologists (ASA) score, tumor location, number of harvested lymph nodes, venous invasion, perineural invasion, adjuvant treatment and PNI (HR = 1.534, 95%CI: 1.065-2.211, P = 0.022; HR = 1.915, 95%CI: 1.286-2.852, P = 0.001 for DFS and OS, respectively) were independent significant prognostic factors for both DFS and OS. CONCLUSIONS: PNI can be a prognostic marker in stage IIA colorectal cancer. J. Surg. Oncol. 2016;114:216-221.
BACKGROUND: The aim of this study was to evaluate systemic inflammatory markers as prognostic factors in patients with stage IIA colorectal cancer. METHODS: Among the patients who underwent curative resection for colorectal cancer at Seoul National University Hospital between 2002 and 2010, 1,035 who were classified as postoperative pathologic stage IIA (T3N0M0) were included. Systemic inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and serum fibrinogen level, were retrospectively reviewed. The patients were divided into two groups according to the cut-off values of the systemic inflammatory markers after receiver operating characteristic (ROC) curve analysis. Survival analysis was performed to identify factors associated with disease-free survival (DFS) and overall survival (OS). RESULTS: Age, American Society of Anesthesiologists (ASA) score, tumor location, number of harvested lymph nodes, venous invasion, perineural invasion, adjuvant treatment and PNI (HR = 1.534, 95%CI: 1.065-2.211, P = 0.022; HR = 1.915, 95%CI: 1.286-2.852, P = 0.001 for DFS and OS, respectively) were independent significant prognostic factors for both DFS and OS. CONCLUSIONS: PNI can be a prognostic marker in stage IIA colorectal cancer. J. Surg. Oncol. 2016;114:216-221.
Authors: Martin Bailon-Cuadrado; Baltasar Perez-Saborido; Javier Sanchez-Gonzalez; Mario Rodriguez-Lopez; Agustin Mayo-Iscar; David Pacheco-Sanchez Journal: Int J Colorectal Dis Date: 2018-06-20 Impact factor: 2.571
Authors: Martin Bailon-Cuadrado; Ekta Choolani-Bhojwani; Francisco J Tejero-Pintor; Javier Sanchez-Gonzalez; Mario Rodriguez-Lopez; Baltasar Perez-Saborido; Jose L Marcos-Rodriguez Journal: Updates Surg Date: 2017-12-08
Authors: Yong Joon Lee; Woo Ram Kim; Jeonghee Han; Yoon Dae Han; Min Soo Cho; Hyuk Hur; Kang Young Lee; Nam Kyu Kim; Byung Soh Min Journal: Ann Coloproctol Date: 2016-12-31