INTRODUCTION: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. METHODS: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. RESULTS: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. CONCLUSIONS: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015-1022, 2016.
INTRODUCTION: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. METHODS: We first performed Rasch analysis on >1,300 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) completed surveys. Results were discussed during a conference call with specialists and biostatisticians. We decided to revise 3 items and prospectively evaluate the revised scale (MG-QOL15r) using either 3, 4, or 5 responses. Rasch analysis was then performed on >1,300 MG-QOL15r scales. RESULTS: The MGQOL15r performed slightly better than the MG-QOL15. The 3-response option MG-QOL15r demonstrated better clinimetric properties than the 4- or 5-option scales. Relative distributions of item and person location estimates showed good coverage of disease severity. CONCLUSIONS: The MG-QOL15r is now the preferred HRQOL instrument for MG because of improved clinimetrics and ease of use. This revision does not negate previous studies or interpretations of results using the MG-QOL15. Muscle Nerve 54: 1015-1022, 2016.
Authors: James F Howard; Vera Bril; Ted M Burns; Renato Mantegazza; Malgorzata Bilinska; Andrzej Szczudlik; Said Beydoun; Francisco Javier Rodriguez De Rivera Garrido; Fredrik Piehl; Mariarosa Rottoli; Philip Van Damme; Tuan Vu; Amelia Evoli; Miriam Freimer; Tahseen Mozaffar; E Sally Ward; Torsten Dreier; Peter Ulrichts; Katrien Verschueren; Antonio Guglietta; Hans de Haard; Nicolas Leupin; Jan J G M Verschuuren Journal: Neurology Date: 2019-05-22 Impact factor: 9.910
Authors: Srikanth Muppidi; Richard J Nowak; Amanda C Guidon; Jeffrey T Guptill; Michael K Hehir; Katherine Ruzhansky; Leeann B Burton; David Post; Gary Cutter; Robin Conwit; Nicte I Mejia; Henry J Kaminski; James F Howard Journal: Muscle Nerve Date: 2021-07-07 Impact factor: 3.852
Authors: James F Howard; Richard J Nowak; Gil I Wolfe; Miriam L Freimer; Tuan H Vu; John L Hinton; Michael Benatar; Petra W Duda; James E MacDougall; Ramin Farzaneh-Far; Henry J Kaminski; Richard Barohn; Mazen Dimachkie; Mamatha Pasnoor; Constantine Farmakidis; Tina Liu; Samantha Colgan; Michael G Benatar; Tulio Bertorini; Rekha Pillai; Robert Henegar; Mark Bromberg; Summer Gibson; Teresa Janecki; Miriam Freimer; Bakri Elsheikh; Paige Matisak; Angela Genge; Amanda Guidon; William David; Ali A Habib; Veena Mathew; Tahseen Mozaffar; John L Hinton; William Hewitt; Deborah Barnett; Patricia Sullivan; Doreen Ho; James F Howard; Rebecca E Traub; Manisha Chopra; Henry J Kaminski; Radwa Aly; Elham Bayat; Mohammad Abu-Rub; Shaida Khan; Dale Lange; Shara Holzberg; Bhupendra Khatri; Emily Lindman; Tayo Olapo; Lisa M Sershon; Robert P Lisak; Evanthia Bernitsas; Kelly Jia; Rabia Malik; Tiffany D Lewis-Collins; Michael Nicolle; Richard J Nowak; Aditi Sharma; Bhaskar Roy; Joan Nye; Michael Pulley; Alan Berger; Yasmeen Shabbir; Amit Sachdev; Kimberly Patterson; Zaeem Siddiqi; Mark Sivak; Joan Bratton; George Small; Anem Kohli; Mary Fetter; Tuan Vu; Lucy Lam; Brittany Harvey; Gil I Wolfe; Nicholas Silvestri; Kara Patrick; Karen Zakalik; Petra W Duda; James MacDougall; Ramin Farzaneh-Far; Angela Pontius; Michelle Hoarty Journal: JAMA Neurol Date: 2020-05-01 Impact factor: 18.302