Josine C van der Heyden1, Erwin Birnie2, Sarah A Bovenberg3, Manuel Castro Cabezas4, Noëlle van der Meulen4, Dick Mul3, Henk J Veeze3, Henk-Jan Aanstoot3. 1. Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, Netherlands; Department of Pediatric Endocrinology, Sophia Children's Hospital, Erasmus MC, University Medical Centre, Rotterdam, Netherlands; Department of Pediatrics, Sint Franciscus Gasthuis, Rotterdam, Netherlands. Electronic address: j.vanderheyden@sfvg.nl. 2. Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, Netherlands; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Netherlands. 3. Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, Netherlands. 4. Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, Netherlands.
Abstract
AIMS: The aim of this study was to assess age-specific carotid intima-media thickness (cIMT) in children and adolescents with type 1 diabetes and to investigate associations between cIMT, age, classical cardiovascular disease (CVD) and other risk factors. METHODS: This study included a cross-sectional analysis of cIMT in 178 patients with type 1 diabetes and 208 healthy controls across age categories. In patients, the impact of gender, socio-economic status, ethnicity, current and historical body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein, and low-density lipoprotein cholesterol on cIMT was studied in a retrospective follow-up cohort study. RESULTS: Median cIMT was equally greater in patients versus controls across all age categories (P≤0.03). Regression models in patients confirmed a lack of association between cIMT and classical CVD risk factors. CONCLUSIONS: Children and adolescents with type 1 diabetes showed greater cIMT than controls in all age categories. Increased cIMT did not seem to be consistently associated with classical adult CVD risk factors, adding to the current debate in pediatrics about the impact on classical CVD risk factors to the development of subclinical atherosclerosis in type 1 diabetes. Future studies are warranted to determine if cIMT could assist in predicting macrovascular complications of type 1 diabetes.
AIMS: The aim of this study was to assess age-specific carotid intima-media thickness (cIMT) in children and adolescents with type 1 diabetes and to investigate associations between cIMT, age, classical cardiovascular disease (CVD) and other risk factors. METHODS: This study included a cross-sectional analysis of cIMT in 178 patients with type 1 diabetes and 208 healthy controls across age categories. In patients, the impact of gender, socio-economic status, ethnicity, current and historical body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein, and low-density lipoprotein cholesterol on cIMT was studied in a retrospective follow-up cohort study. RESULTS: Median cIMT was equally greater in patients versus controls across all age categories (P≤0.03). Regression models in patients confirmed a lack of association between cIMT and classical CVD risk factors. CONCLUSIONS:Children and adolescents with type 1 diabetes showed greater cIMT than controls in all age categories. Increased cIMT did not seem to be consistently associated with classical adult CVD risk factors, adding to the current debate in pediatrics about the impact on classical CVD risk factors to the development of subclinical atherosclerosis in type 1 diabetes. Future studies are warranted to determine if cIMT could assist in predicting macrovascular complications of type 1 diabetes.
Authors: Fariba Ahmadizar; Patrick Souverein; Anthonius de Boer; Anke H Maitland-van der Zee Journal: Br J Clin Pharmacol Date: 2018-01-25 Impact factor: 4.335
Authors: Rita Delphine Maiko Varkevisser; Erwin Birnie; Charlotte E Vollenbrock; Dick Mul; Peter R van Dijk; Melanie M van der Klauw; Henk Veeze; Bruce H R Wolffenbuttel; Henk-Jan Aanstoot Journal: BMJ Open Diabetes Res Care Date: 2022-07