| Literature DB >> 27216998 |
Pongkorn Chaiyakunvat1, Natthinee Anantachoke2, Vichai Reutrakul1, Chutima Jiarpinitnun1.
Abstract
Total of 22 caged xanthones were subjected to susceptibility testing of global epidemic MRSA USA300. Natural morellic acid showed the strongest potency (MIC of 12.5μM). However, its potent toxicity diminishes MRSA therapeutic potential. We synthetically modified natural morellic acid to yield 13 derivatives (3a-3m). Synthetically modified 3b retained strong potency in MRSA growth inhibition, yet the toxicity was 20-fold less than natural morellic acid, permitting the possibility of using caged xanthones for MRSA therapeutic.Entities:
Keywords: Bacterial invasion; Caged xanthones; Methicillin resistant Staphylococcus aureus; USA300
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Year: 2016 PMID： 27216998 DOI： 10.1016/j.bmcl.2016.05.030
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823