Literature DB >> 27216868

New [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes.

Pedro R Florindo1, Diane M Pereira2, Pedro M Borralho2, Paulo J Costa3, M F M Piedade4, Cecília M P Rodrigues2, Ana C Fernandes1.   

Abstract

Eight ruthenium(ii) compounds of the general formula [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC50 between 14.56 and 1.56 μM; importantly, compounds 5Ru and 6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27216868     DOI： 10.1039/c6dt01571a

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  2 in total

1.  Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands.

Authors:  Bence Balázs; Zoltán Tóth; István Kacsir; Adrienn Sipos; Péter Buglyó; László Somsák; Éva Bokor; Gábor Kardos; Péter Bai
Journal:  Front Chem       Date:  2022-04-12       Impact factor: 5.545

2.  Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.

Authors:  István Kacsir; Adrienn Sipos; Attila Bényei; Eszter Janka; Péter Buglyó; László Somsák; Péter Bai; Éva Bokor
Journal:  Int J Mol Sci       Date:  2022-01-12       Impact factor: 5.923
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.